Bridgestone Corporation

Badan Pengkajian Dan Penerapan Teknologi

Tomoki Sando

Akio Kobayashi

Norie Watanabe

Eiichiro Fukusaki

Teuku Tajuddin

Nadirman Haska

Koichiro Gyokusen

Eiichiro Fukuzaki

Haska Nadirman

Purbowasito Wahyu

According to this invention, a gene cluster involved in the non-mevalonate pathway ofwas obtained and nucleotide sequences of these genes were determined. The gene cluster according to this invention involved in the IPP biosynthesis in the non-mevalonate pathway is involved in the biosynthesis of vitamin E and carotenoids. Therefore, theobtained by introducing the gene cluster of the present invention can be expected to produce high-quality rubber with improved permanence.

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According to the present invention, a gene cluster encoding various kinds of prenyl transferase ofis obtained, and the nucleotide sequences of these genes are determined. The prenyl transferases are involved in the biosynthesis of isoprene backbone of natural rubber. Therefore, improvement of productivity of rubber can be expected, by transforming plants by the gene cluster obtained in the present invention.

It is a subject of this invention to isolate a gene group of enzymes involved in the biosynthesis of vitamin E of Para rubber tree, and to determine the base sequence of each gene. According to this invention, genes encoding enzymes involved in the vitamin E biosynthesis were isolated from Para rubber tree and the base sequences of these genes were determined. Since vitamin E is an antioxidant existing in nature, it is expected that transformation of a plant by using the genes obtained in the invention would result in an increase in the vitamin E content of the plant and, in its turn, contribute to the prevention of rubber from aging.

Homogentisic acid geranylgeranyl transerase polypeptide

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Kodaira, Japan

Tomoki Sando