Shionogi Company Limited

Tomokazu Yoshinaga

Toshio Fujishita

Akihiko Sato

Kouhei Nodu

Takashi Kawasuji

Takashi Shionogi & Co Ltd Kawasuji

The present invention relates to a novel compound having an antiviral effect, more specifically, a pyridone derivative having HIV integrase inhibitory activity, and a medicament containing the same, in particular, an anti-HIV agent. The compound of the present invention has integrase inhibitory activity and/or cell proliferation inhibitory activity against viruses, in particular, HIV and drug-resistant strains thereof. Thus, the compound is useful in preventing or treating various diseases, viral infections (for example, AIDS), and the like in which integrase participates.

Polycyclic pyridone derivative having integrase inhibitory activity

A compound of the formula (I): wherein X is hydroxy or the like;

Integrase inhibitors containing aromatic heterocycle derivatives

A compound of the formula (I):wherein X is hydroxy, protected hydroxy or optionally substituted amino; Y is &#x2014;COORwherein Ris hydrogen or ester residue, &#x2014;CONRRwherein Rand Reach is independently hydrogen or amide residue, optionally substituted aryl or optionally substituted heteroaryl; and Ais optionally substituted heteroaryl; provided that a compound wherein Y and/or Ais optionally substituted indol-3-yl is excluded, a tautomer, a prodrug, a pharmaceutically acceptable salt or a hydrate thereof has an inhibitory activity against an integrase.

Heteroaromatic derivatives having an inhibitory activity against HIV integrase

Indole derivatives having an antiviral activity

Aromatic heterocycle compounds having HIV integrase inhibiting activities

Indole derivatives with antiviral activity

Growing community of inventors

Osaka, Japan

Tomokazu Yoshinaga