Taisho Pharmaceutical Co., Ltd.

Tomokazu Tamaoki

Yohei Kobashi

Yohei Matsuda

Norikazu Otake

Daisuke Matsuda

Hideaki Tabuse

Minoru Moriya

Rie Shimono

A novel process for producing optically active 2-(2-fluorobiphenyl-4-yl)propanoic acid is disclosed. This production process is characterized in that a compound of formula [1] is reacted with magnesium and so forth to prepare an organometallic reagent, which is reacted with a compound of formula [2] in the presence of a catalytic amount of a nickel compound and a catalytic amount of an optically active compound of formula [3] to obtain a compound represented by formula [4] which is subsequently converted to a compound represented by formula [5] or a pharmaceutically acceptable salt thereof. 

Method for producing optically active 2-(2-fluorobiphenyl-4-yl) propanoic acid

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Tokyo, Japan

Tomokazu Tamaoki