Chugai Seiyaku Kabushiki Kaisha

Tomokazu Ozaki

Tatsuya Kato

Toru Esaki

Yoshiyuki Suzuki

Kunihiro Hattori

Nobuhiro Ohi

Michitaka Akima

Toshiro Kozono

Kazuya Nakagomi

Yoshikazu Kumagai

Shinya Fujiwara

Kazuhiko Tamura

The compounds of the invention are compounds represented by the following general formula (1):wherein E represents one selected from the group consisting of a methylidyne group and a nitrilo group, Rrepresents one selected from the group consisting of optionally substituted aryl groups and optionally substituted heteroaryl groups, Rrepresents one selected from the group consisting of a hydrogen atom and alkyl groups, Wrepresents an amino acid residue, A represents one selected from the group consisting of a carbonyl group and a sulfonyl group, Xrepresents one selected from the group consisting of optionally substituted alkylene groups and optionally substituted alkenylene groups, and p represents 0 or 1;and their pharmacologically acceptable salts, which exhibit thrombopoietin-like activity.

Compounds exhibiting thrombopoietin-like activities

Disclosed are crystals of a compound represented by the formula:

Crystalline fumarate of 2-phenyl-1, 3-thiazolidine-4-on derivative

The present invention is directed to a compound represented by formula (I): wherein, for example, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 each represents a hydrogen atom; R.sub.6 and R.sub.7 each represent a substituted or unsubstituted lower alkyl group; A represents a group represented by formula (II): ##STR1## wherein R.sub.5 represents, for example, a hydrogen atom; and n represents an integer of 2 to 6, or a stereoisomer or optical isomer thereof and a pharmaceutically acceptable salt thereof and compositions and methods for treating ischemic diseases. The compounds represented by formula (I) have an inhibitory action on calcium overload in addition to a vasorelaxing activity (calcium antagonism) and an inhibitory action on lipid peroxidation and are useful as a preventive or treating agent for ischemic diseases and hypertension.

Benzene derivatives, compositions and methods for treating ischemic

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Gotenba, Japan

Tomokazu Ozaki