Kawasumi Laboratories. Inc.

Shiga University of Medical Science

Taki Chemical Co., Ltd.

Japan As Represented by Director General of National Institute of Health Sciences

Tomokazu Mukai

Tsuyoshi Kawakami

Noriaki Shirahama

Takao Okada

Toru Tani

Toshiyasu Yuba

Yukari Imamura

Yoshimichi Fujiyama

Sumihiro Kamitani

Yusuke Nomura

Mariko Sei

Kazuo Isama

Noriaki Kawasumi Laboratories Inc Shirahama

An object of the present invention is to provide an anti-adhesion material having sufficient in vivo degradability and excellent anti-adhesion characteristics, and also superior to conventional ones in terms of handling properties under wet conditions. The anti-adhesion material () of the present invention has a sheet-like base layer () containing a water soluble polymer (e.g., pullulan), a first cover layer () placed on a surface on one side of the base layer () and containing an aliphatic ester, and a second cover layer () placed on a surface on the other side of the base layer () and containing an aliphatic ester. The optical thickness of each of the first cover layer () and the second cover layer () is set to be 27 nm or greater and smaller than 160 nm.

Anti-adhesion material

Provided are an artificial dura mater having a laminated constitution of at least two layers of in vivo degradable polymers, at least one layer of them being a substrate layer, the substrate layer being formed of a lactic acid/glycolic acid/&#x3b5;-caprolactone copolymer, the copolymer having a component molar ratio of 60-85:3-15:10-30 mol % and the copolymer having an average chain length that satisfies the following expressions (1) to (3) and a process for the production thereof, and when this artificial dura mater is used, no liquid leakage is caused since the bloating of suture holes is small, and the period of time for which it retains its strength is suitably a little longer than the period of time required for the regeneration of an autodura mater,2&#x3c;()&#x3c;[%/(%+%+%)]&#xd7;&#xd7;0.058&#x2003;&#x2003;(1)1&#x3c;()&#x3c;[%/(%+%+%)]&#xd7;&#xd7;0.58&#x2003;&#x2003;(2)1&#x3c;()&#x3c;[%/(%+%+%)]&#xd7;&#xd7;0.58&#x2003;&#x2003;(3) wherein L(LA), L(GA) and L(CL) represent average chain lengths of lactic acid units, glycolic acid units and of caprolactone units, LA%, GA% and CL% represent molar ratios of a lactic acid component, a glycolic acid component caprolactone component in the copolymer and X is a polymerization degree of the copolymer.

Artificial dura mater and process for producing the same

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Kanagawa, Japan

Tomokazu Mukai