The Green Cross Corporation

Tomokazu Gotoh

Chikara Fukaya

Masanori Sugiura

Shigeki Kuwahara

Masahiko Kajii

Naoki Sugiyama

Yoshiko Tanaka

Takao Kondoh

Fumihiko Akaboshi

Haruko Yakumaru

Aminophenol derivatives of the following formula (I) ##STR1## wherein X is hydrogen atom, lower alkyl or a protecting group for phenolic hydroxy, Y is hydrogen atom or lower alkyl, Z is hydrogen atom, lower alkyl, halogen atom or trifluoromethyl, A is hydrogen atom or lower alkyl, t is an integer of 1 to 5, l and m are respectively an integer of 2 to 4, E and W are nitrogen atoms, F is a direct bond or oxygen atom, P and Q are each hydrogen atom, halogen atom, lower alkyl or lower alkoxy, and R.sup.8 is hydrogen atom, hydroxy or a hydroxy-protecting group, and their pharmcologically acceptable salts. Since the aminophenol derivatives (I) of the present invention have excellent antioxidative action and antiinflammatory and antiallergic action in mammalian animals including human, they are extremely useful as pharmaceuticals such as an antiinflammatory or an antiallergic.

Substituted or unsubstituted benzhydryl heteroalkyl-substituted

Growing community of inventors

Hirakata, Japan

Tomokazu Gotoh