Ube Industries, Inc.

Santen Pharmaceutical Co., Ltd.

Tomokazu Fujimoto

Masahiko Hagihara

Ken-ichi Komori

Hiroshi Nishida

Yasunori Tsuzaki

Kazutaka Kido

Takeshi Matsugi

Hidetoshi Sunamoto

Atsushi Shimazaki

Akira Takama

Ken-Ichi Komori

A compound represented by formula (1) or salt thereof and a production intermediate thereof are created. The compound exhibited an excellent antioxidation action in a microsome lipid peroxidation measuring system using a rat liver microsome. Therefore, the compound or salt thereof is useful as an antioxidant. The present invention also provides use of a compound represented by the formula (1) or a pharmaceutically acceptable salt thereof for production of an antioxidant. 

Indazole derivative or salt thereof and production intermediate thereof, and antioxidant using same, and use of indazole derivative or salt thereof

An object of the present invention is to create a novel indazole derivative having a spiro ring structure in a side chain, which is useful as a pharmaceutical, and to find a new pharmacological activity of the derivative. The present invention compound is represented by the general formula [I] and has an excellent Rho kinase inhibitory activity. In the formula, the ring X represents a benzene ring or a pyridine ring; Rand Rrepresent halogen, H, OH, alkoxy, cycloalkyloxy, aryloxy, alkyl, cycloalkyl or the like; Rrepresents halogen, H or the like; Rand Rrepresent halogen, H or the like; Rand Rrepresent H, alkyl or the like; and m, n, p and q represent an integer of 0 to 3. In this connection, each group may have a substituent.

Indazole derivative having spiro ring structure in side chain

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Osaka, Japan

Tomokazu Fujimoto