Fujisawa Pharmaceutical Company, Ltd.

Tomohito Oku

Hiroshi Kayakiri

Noritsugu Yamasaki

Takafumi Imoto

Hitoshi Sawada

Takahiro Hiramura

Miho Kawauchi

Noriko Oku

Chikako Oku

The present invention provides novel benzimidazole derivatives of the following formula (I) and salts thereof:wherein Rrepresents a lower alkyl group or a lower alkyloxy-lower alkyl group; Rrepresents a hydrogen atom, a halogen atom, an alkyl group having 1 to 8 carbon atoms, an aryl group, and such; Rrepresents a lower alkyl group, a lower alkenyl group, an aryl group, a lower alkylaryl group, an aryl-lower alkenyl group, a halothienyl group, a lower alkylamino group, or an aryl-lower alkylamino group; A represents a benzene ring, a naphthalene ring, or a pyridine ring; and X represents a halogen atom. The derivatives and their salts have blood sugar level-depressing activity or PDE5-inhibiting activity, and are useful as pharmaceutical preparations.

Benzimidazole derivatives

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Takatsuki, Japan

Tomohito Oku