Taiho Pharmaceutical Company Limited

Synphar Laboratories, Inc.

Tomohiro Yamashita

Hiroshi Matsumoto

Rajeshwar Singh

Ronald J Micetich

Toshio Otani

Shinji Oie

Tetsuji Asao

Yukio Tada

Yoshimitsu Suda

Charles Y Fiakpui

George Thomas

Chan M Ha

Shozo Yamada

Shigeo Okajima

Kazuhiko Shigeno

Nobuhiko Katunuma

Nobuhiko Katsunuma

Atsuhiko Uemura

Toshiyuki Toko

Zhang Q Rong

Zhen J Sheng

Zhang Z Ping

Singh Rajeshwar

Zhang J Liang

Mark Tempest

Epoxysuccinamide derivative or salt thereof

3-(substituted methyl)-4-oxa-1-azabicyclo[3.2.0]heptan-7-one derivatives

Epoxysuccinamide derivative or salt thereof, and medicine comprising the

3-(7-oxo-1-aza-4-oxabicyclo[3.2.0]hept-3-yl)alanine derivative as

A derivative of 3-(7'-oxo-1'-aza-4'-oxabicyclo[3.2.0 ]hept-3'-yl)propionic acid represented by the formula ##STR1## wherein R.sub.1 is a hydrogen atom, a lower alkyl group optionally having one or more cycloalkyl groups, a lower acyl group, a benzoyl group optionally having one or more substituents or a benzyl group optionally having one or more substituents, R.sub.2 is a hydrogen atom or a carboxyl-protecting group, R.sub.3 is a hydroxyl group, an azido group, a benzenesulfonyloxy group optionally having one or more substituents, a lower alkylsulfonyloxy group optionally having one or more substituents, a tri-substituted silyloxy group or an amino group optionally having one or more substituents, provided that when R.sub.1 and R.sub.2 are hydrogen atoms, R.sub.3 is not an amino group, and a salt thereof.

3-(7'-oxo-1'-aza-4'-oxabicyclo[3.2.0]-hept-3'-YL)propionic acid

4-oxa-1-azabicyclo [3,2,0] heptan-7-one derivatives as antitumor agents

Growing community of inventors

Hidaka, Japan

Tomohiro Yamashita