Kao Corporation

Tomohiro Shirai

Kentaro Kumihashi

Hiroshi Kusuoku

Mitsuyoshi Sakasai

Hiroshi Hashimoto

Hirohisa Fujihara

Nanae Mugita

Kazuki Kinoshita

The present invention provides a processed plant product having an excellent TRPM8 activating action, a method for producing the same, and a cooling agent and a TRPM8 activator comprising the processed plant product. A method for producing a processed nutmeg product, comprising a step of simultaneously treating nutmeg or an extract thereof with an alcohol or a 25% (v/v) or more alcohol aqueous solution and one or more selected from a protonic acid and an H-type cation exchange resin.

Processed nutmeg product and method for producing same

Provision of a TRPA1 activity inhibitor capable of reducing sensory irritation to skin or mucous membrane and an agent for reduction of sensory irritation for skin or mucous membrane. A TRPA1 inhibitor and an agent for reduction of sensory irritation for skin or mucous membrane comprising as an active ingredient a compound represented by the following formula (1) wherein Rand Reach independently represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, Rrepresents an alkyl group having 1 to 6 carbon atoms, Rrepresents a hydrogen atom, a methyl group or an ethyl group, and a double line composed of a dotted line and a solid line represents a single bond or a double bond. 

Agent for reduction of sensory irritation

Provided are a cooling agent having an excellent TRPM8 activating action, a TRPM8 activator, a method for imparting cooling sensation, and a novel compound useful for imparting cooling sensation. Disclosed is a cooling agent comprising, as an active ingredient, a compound represented by the following formula (1): wherein Rrepresents a hydrogen atom; Rrepresents a hydrogen atom, a hydroxyl group, or an alkoxy group having from 1 to 3 carbon atoms; Rrepresents a hydrogen atom or a hydroxyl group; Rrepresents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, an alkenyl group having from 2 to 6 carbon atoms, or an alkoxy group having from 1 to 3 carbon atoms; Rrepresents a hydrogen atom or an alkoxy group having from 1 to 3 carbon atoms; and Rrepresents a hydrogen atom, a hydroxyl group, an alkoxy group having from 1 to 14 carbon atoms, an alkoxyalkoxy group having from 2 to 12 carbon atoms in total, a cycloalkoxy group having from 3 to 12 carbon atoms, an aryloxy group having from 6 to 12 carbon atoms, an aralkyloxy group having from 7 to 14 carbon atoms in total, or an alkanoyloxy group having from 2 to 12 carbon atoms in total.

Cooling agent and TRPM8 activator

Growing community of inventors

Utsunomiya, Japan

Tomohiro Shirai