Canon Kabushiki Kaisha

Novartis Ag

Ricoh Company, Ltd.

Tomohiro Shima

Koki Kodaira

Oliver Sander

Charis Papavassilis

Susumu Kitamura

Kei Oikawa

Yuta Moriya

Yusuke Iwaki

Tatsurou Fujii

Hitoshi Nakashige

The disclosure is directed to methods, treatment regimens, uses, kits and therapies for treating Generalized Pustular Psoriasis (GPP). These methods, treatment regimens, uses, kits and therapies utilize, inter cilia, administration of an IL-17 antagonist, e.g., an IL-17 antibody, such as secukinumab. Additionally disclosed are improved methods for treating plaque-type psoriasis that utilize up-titration and down-titration of the IL-17 antagonist, e.g., an IL-17 antibody, such as secukinumab, as well as modification of dose frequency. Further disclosed are methods of treating palmoplantar pustular psoriasis using the disclosed IL-17 antagonists, e.g., IL-17 antibodies, such as secukinumab.

Methods of treating palmoplantar pustular psoriasis (PPP) using IL-17 antibody

A resin shaping mold includes a hot runner, a cavity, a cold runner, and a valve pin. The cold runner is connected to the hot runner and the cavity. The cold runner has a lower temperature than the hot runner. The valve pin configured to move forward and backward from the hot runner toward the cold runner and close a channel of molten resin from the hot runner to the cavity at a predetermined position. The valve pin includes a runner lock portion configured to hold resin solidified at a position further on the cavity side with respect to the predetermined position in the cold runner.

Resin shaping mold and method of producing resin molded product

A filler-containing resin molded product with a surface which includes irregularities which are transferred from a mold cavity to the surface and have an arithmetic mean roughness of 0.8 &#x3bc;m or greater and 10 &#x3bc;m or less and a peak arithmetic mean curvature of 400 [1/mm] or greater and 900 [1/mm] or less.

Resin molded product, interchangeable lens for camera, and method of manufacturing resin molded product

The disclosure is directed to methods, treatment regimens, uses, kits and therapies for treating Generalized Pustular Psoriasis (GPP). These methods, treatment regimens, uses, kits and therapies utilize, inter alia, administration of an IL-17 antagonist, e.g., an IL-17 antibody, such as secukinumab. Additionally disclosed are improved methods for treating plaque-type psoriasis that utilize up-titration and down-titration of the IL-17 antagonist, e.g., an IL-17 antibody, such as secukinumab, as well as modification of dose frequency. Further disclosed are methods of treating palmoplantar pustular psoriasis using the disclosed IL-17 antagonists, e.g., IL-17 antibodies, such as secukinumab.

Methods of treating generalized pustular psoriasis (GPP) using IL-17 antagonists

Growing community of inventors

Tokyo, Japan

Tomohiro Shima