Daiichi Sankyo Company, Limited

Tomohiro Nishizawa

Takahiro Yamaguchi

Tohru Takahashi

Ryuji Hashimoto

Shinji Yamaguchi

Christine Rothe

Andrea Allersdorfer

Marlon Hinner

Andreas Hohlbaum

Alexander Wiedenmann

Gabriele Matschiner

Rachida Siham Bel Aiba

Keiko Suzuki

Akihiro Tamura

Bradley Lunde

Futoshi Nara

Takahide Aburatani

Chikako Nagasaki

Mitsuhiro Yamaguchi

The present disclosure relates to novel lipocalin muteins which bind to PCSK9. The disclosure also provides corresponding nucleic acid molecules encoding lipocalin muteins and methods for producing lipocalin muteins as well as their encoding nucleic acid molecules.

Nucleic acid molecules encoding muteins of human tear lipocalin which bind PCSK9

Human tear lipocalins which bind PCSK9 and methods of use thereof

The present invention provides a compound having excellent regulating action on blood lipid level. The present invention provides a compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof, etc., wherein A represents a 5-membered nitrogen-containing aromatic heterocyclyl group; Rrepresents COOH or the like; each Rrepresents an alkyl or the like; each Rrepresents an optionally substituted phenyl, an optionally substituted phenylalkyl, or the like; m represents 0, 1, 2, or 3; n represents 0 or 1; each of R, R, R, and Rrepresents H, an alkyl, or the like; and B represents an optionally substituted naphthyl, an optionally substituted aromatic heterocyclyl, or a group represented by the following formula (II) wherein each of Band Brepresents an optionally substituted phenyl or an optionally substituted aromatic heterocyclyl. 

Nitrogen-containing aromatic heterocyclyl compound

The present invention provides a compound having excellent regulating action on blood lipid level that is represented by the following general formula (I) or a pharmacologically acceptable salt thereof, wherein, in one embodiment, A represents a 5-membered nitrogen-containing aromatic heterocyclyl group; Rrepresents COOH; each Rrepresents an alkyl; each Rrepresents an optionally substituted phenyl, an optionally substituted phenylalkyl; m represents 0, 1, 2, or 3; n represents 0 or 1; each of R, R, R, and Rrepresents H, an alkyl; and B represents an optionally substituted naphthyl, an optionally substituted aromatic heterocyclyl, or a group represented by the following formula (II) wherein each of Band Brepresents an optionally substituted phenyl or an optionally substituted aromatic heterocyclyl. 

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Tokyo, Japan

Tomohiro Nishizawa