Kobe Steel, Ltd.

Kabushiki Kaisha Kobe Seiko Sho

Juridical Foundation the Chemo-sero-therapeutic Research Institute

Kumamoto University

Tokyo Metropolitan Institute of Medical Science

National University Corporation Kumamoto University

Tomohiro Nishimura

Masaaki Sato

Masayuki Takada

Takashi Inaba

Jun Takigawa

Toshiki Ueda

Hideo Fujimoto

Masao Takemoto

Yoshinori Kato

Kenji Tokuda

Jitsuto Shikata

Masaharu Kaifu

Kenji Harada

Michinori Kohara

Masanori Ikeda

Akihiro Tsuruno

Fumihiro Koshigoe

Yasuhiro Nishioka

Masaki Tanigawa

Kazuo Tanaka

Makoto Morishita

Naoki Sakashita

Kyoko Kohara

Kikuo Toyose

Yagoro Hirose

Junu Hirai

Yasunori Nishioka

The present invention aims to provide hepatitis C virus inhibitors capable of inhibiting viral replication in hepatitis C virus-infected cells. The replication of hepatitis C virus can be inhibited and hepatitis C virus-infected cells can be specifically injured by specifically inhibiting BGT-1 or AKR1C1 involved in the replication of hepatitis C virus. Thus, viral inhibitors comprising a substance inhibiting BGT-1 or AKR1C1 are effective for the treatment of hepatitis C.

Hepatitis C virus inhibitors

Skin material of a clad material is composed of one or more layers, each layer of the skin materials is made of a metal different from the core material in their component compositions, and at least one layer of the skin material has a cast microstructure, when the skin material is superposed on either of one or both faces of the core material.

Method for manufacturing clad material and equipment for manufacturing the same

Equipment for manufacturing skin material of a clad material includes a casting apparatus which melts and mixes a metal for the skin material different from the core material in their component compositions, and casts the skin material; an ingot-cutting apparatus which cuts an ingot for skin material which is cast by the casting apparatus; and a conveying apparatus which conveys the ingot for skin material among each apparatus. The ingot-cutting apparatus is a slicing apparatus which slices the ingot for skin material into a predetermined thickness.

A method for manufacturing a clad material composed of a core material and one or more skin materials which are superposed on either one or both faces of the core material, includes a clad material preparation process where an ingot for core material is manufactured by dissolving and casting a metal, and an ingot for skin material is manufactured by dissolving and casting a different metal for skin material, without hot rolling. The ingot for skin material is superposed as a skin material at a predetermined position of either one or both faces of the ingot for core material and the superposed material is hot-rolled to manufacture a clad material.

A method for manufacturing a clad material composed of a core material and one or more skin materials which are superposed on either one or both faces of the core material, includes a clad material preparation process where an ingot for core material is manufactured by melting and casting a metal, and an ingot for skin material is manufactured by melting and casting a different metal for skin material, without hot rolling. The ingot for skin material is superposed as a skin material at a predetermined position of either one or both faces of the ingot for core material and the superposed material is hot-rolled to manufacture a clad material.

A high strength, corrosion-resistant alloy for brazing is disclosed, which alloy comprises 0.2-1.0 wt % of Cu, 0.1-0.5 wt % of Mg, 0.2-1.0 wt % of Si, and the balance of Al and inevitably present impurities. The weight ratio of Si/Mg is in the range of 1-2.5:1. The alloy may further comprise 0.03-0.5 wt % of Ni and/or one or more of Zr, Cr and Mn each in an amount of 0.05-0.5 wt %.

High strength, corrosion-resistant aluminum alloys for brazing

A high strength, corrosion-resistant alloy for brazing is disclosed, which alloy comprises 0.2-1.0 wt % of Cu 0.1-0.5 wt % of Mg, 0.2-1.0 wt % of Si, and the balance of Al and inevitably present impurities. The weight ratio of Si/Mg is in the range of 1-2.5:1. The alloy may further comprise 0.05-0.5 wt % of Ni and/or one or more of Zr, Cr and Mn each in an amount of 0.05-0.5 wt %.

An aluminum brazing sheet for use in brazing comprises;

Aluminum brazing sheet

Aluminum alloy composite materials for brazed heat exchangers are described, which comprise an Al core alloy essentially consisting of predetermined amounts of Si, Mg, Cu and at least one element selected from Mn, Cr and Zr, the balance being Al and inevitable impurities, and an Al alloy clad layer formed on one side of the core alloy which is in contact with an aqueous heat transfer medium. The clad layer has a thickness 3-20% based on the thickness of the composite material and a less-noble corrosion potential of 20-100 mV than the core alloy. A filler alloy may be formed on the other side of the core alloy.

Aluminum alloy composite materials for brazed heat exchangers

An aluminum-base brazing alloy containing essentially up to 2 wt % of Cu, 0.01 to 0.08 wt % of Ti, and the balance of Al and unavoidable impurities, with or without at least one component selected from the group consisting of 0.01 to 0.5 wt % of Zr, 0.05 to 0.5 wt % of Mn and 0.05 to 0.5 wt % of Cr.

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Moka, Japan

Tomohiro Nishimura