Chugai Seiyaku Kabushiki Kaisha

Tomohiro Neichi

Yasushi Murakami

Shun-Ichi Hata

Yukifumi Noda

Hiroshi Nakakimura

Takashi Mori

Sakae Takaku

Tamotsu Yamazaki

Masuo Koizumi

Takashi Matsuno

Shigeyuki Kataoka

Hiroshi Matsushita

Shigeru Takanashi

Masamitsu Honda

Kazuo Sasahara

Fumiaki Matsuura

Dibenzoxazepine derivatives of the formula: ##STR1## wherein R.sub.1, n, R.sub.2 and R.sub.3 are as defined in the description, process for preparing the same, pharmaceutical composition containing the same and method of treating diseases in circulatory organs administering the composition to a patient are disclosed. The compounds of the formula have lipid lowering activity, lipid peroxide lowering activity, blood sugar lowering activity and activity to inhibit the aggregation of platelets, and hence are useful as a medicine.

Dibenzoxazepine derivative, and pharmaceutical composition comprising

Novel compound, 1,2-bis(nicotinamido)propane and its pharmaceutically acceptable salts, a process for preparing the same and a pharmaceutical composition containing the same as an active ingredient are disclosed. The compound acts to prevent or spasmolyse cerebral vasospasms, to prevent cerebral apoplexy and to lower the lipoperoxide level in blood.

Nicotinamide derivative, process for preparing the same and

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Tokorozawa, Japan

Tomohiro Neichi