Shimadzu Corporation

Tomohiro Gomi

Daisuke Kitabayashi

Shinya Imamura

Keisuke Ogawa

Masahide Gunji

Masataka Nikko

A liquid sending failure detector acquires periodically a liquid sending pressure of a liquid sending mechanism consecutively sends liquid using at least one plunger pump that sends liquid by reciprocally driving a plunger such that a fluctuation is read in one driving period of the liquid sending mechanism, and detect a liquid sending failure of the liquid sending mechanism using an acquired liquid sending pressure. The liquid sending failure detector executes a pulsation detection step of obtaining a fluctuation range of the liquid sending pressure in a certain driving period of the liquid sending mechanism and detecting pulsation on a condition that a count of consecutive periods in which the fluctuation range exceeds a predetermined reference value exceeds a predetermined reference count, and a liquid sending failure detection step of detecting a liquid sending failure of the liquid sending mechanism when the pulsation is detected in the pulsation detection step.

Liquid sending system for liquid chromatograph

A liquid sending system includes a plurality of liquid sending pumps that operate independently from one another and send a mobile phase into a common flow path, a pressure sensor for detecting a liquid sending pressure in the flow path, and a liquid sending failure detector configured to detect a liquid sending failure caused by any of the plurality of liquid sending pumps by periodically acquiring a liquid sending pressure detected by the pressure sensor and detecting a fluctuation of the liquid sending pressure associated with a driving period of each of the plurality of liquid sending pumps.

A liquid chromatograph includes a liquid sending pump for sending a mobile phase, a sample injector that injects a sample into an analysis flow path through which a mobile phase from the liquid sending pump flows, a separation column that is provided on the analysis flow path and is to separate a sample that has been injected into the analysis flow path by the sample injector into components, a pressure sensor for detecting a liquid sending pressure in the analysis flow path located at a position farther upstream than the separation column, a damper capacity holder that holds an internal capacity of a system through which a mobile phase from the liquid sending pump flows as a damper capacity, a reference value determiner configured to determine a reference value of a fluctuation range of the liquid sending pressure when a liquid sending failure of the liquid sending pump occurs, using at least the damper capacity held by the damper capacity holder, and a liquid sending failure detector that is configured to periodically acquire a liquid sending pressure detected by the pressure sensor, obtain a fluctuation range of the liquid sending pressure in a certain driving period of the liquid sending pump and detect a liquid sending failure using the obtained fluctuation range and the reference value determined by the reference value determiner.

Liquid chromatograph

Liquid sent by a liquid sending pump flows through an analysis flow path. A sample is injected into the analysis flow path. A separation column is provided in the analysis flow path. A sample injected in the separation column is separated into components, and sample components obtained by separation are detected by a detector. The number of liquid sending pumps and a connection structure of the liquid sending pumps connected to the analysis flow path are specified by a system configuration specifier as a system configuration. A condition for detecting a liquid sending failure in a liquid sending pump that is preset for each type of system configuration is held by a condition holder. A condition corresponding to a system configuration is determined from conditions held by the condition holder. A liquid sending failure in a liquid sending pump is detected with use of the determined condition.

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Kyoto, Japan

Tomohiro Gomi