Kyowa Hakko Kirin Co., Limited

Kyowa Kirin Co., Ltd.

Tomohiro Era

Takeshi Kuboyama

Tomoyuki Naoi

Shintaro Hosoe

Kaori Yagi

Provided are a cationic lipid which facilitates the introduction of a nucleic acid into, for example, a cell or the like; a composition containing the cationic lipid and a nucleic acid; a method for introducing a nucleic acid into a cell by using a composition containing the cationic lipid and the nucleic acid; and the like. The cationic lipid is, for example, a cationic lipid represented by formula (A): formula (A): (wherein Ris alkenyl or the like, Ris alkenyl or the like, Rand Rare each alkyl, or are combined together to form alkylene, or Rand Rare combined together to form alkylene, Ris a hydrogen atom or the like, or is combined together with Rto form alkylene, Xis alkylene, and Xis a single bond or alkylene).

Cationic lipid

The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I) 

The present invention provides a lipid nano-particles, which allow nucleic acids to be easily introduced into cells, comprising a cationic lipid represented by formula (I) (wherein: Rand Rare, the same or different, alkenyl, etc, and 

Lipid nano particles comprising cationic lipid for drug delivery system

The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I) (wherein: Rand Rare, the same or different, alkenyl, etc, and Xand Xare hydrogen atoms, or are combined together to form a single bond or alkylene, and Xis absent or is alkyl, etc, Y is absent or anion, a and b are, the same or different, 0 to 3, and Lis a single bond, etc, Ris alkyl, etc, Land Lare &#x2014;O&#x2014;, &#x2014;CO&#x2014;O&#x2014; or &#x2014;O&#x2014;CO&#x2014;), a composition comprising the cationic lipid and a nucleic acid, and a method for introducing a nucleic acid into a cell by using the composition comprising the cationic lipid and the nucleic acid, and the like. 

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Tokyo, Japan

Tomohiro Era