Kyowa Hakko Kirin Co., Limited

Tomohiro Danjo

Takashi Sawada

Takayuki Furuta

Noriaki Uesaka

Takahiro Nakajima

Masamori Sugawara

Keiichi Motosawa

Maki Ichioka

The ring-fused heterocyclic compound or a pharmaceutically acceptable salt thereof according to the present invention has a T-type calcium channel regulatory effect, and is useful, for example, as a medicament for treating and/or preventing pruritus. The present invention provides a ring-fused heterocyclic compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof and the like which has a T-type calcium channel regulatory effect and is useful as a therapeutic and/or preventive agent for pruritus, and the like. [wherein, Rrepresents optionally substituted lower alkyl and the like, Rrepresents optionally substituted lower alkyl and the like, Rrepresents the formula (II): (wherein, n represents 0 or 1, Rrepresents a hydrogen atom and the like, Rrepresents a hydrogen atom and the like, and Rrepresents a hydrogen atom and the like) and the like, Q represents a hydrogen atom and the like, and Wrepresents a nitrogen atom and the like, Wrepresents a nitrogen atom and the like].

Ring-fused heterocyclic compound

A ring-fused heterocyclic derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof having a T-type calcium channel regulatory effect and useful as a pruritus therapeutic and/or preventive agent, and the like are provided. In the general formula (I), Rrepresents optionally substituted lower alkyl, and the like; Rrepresents an optionally substituted cycloalkyl, and the like; Q represents a hydrogen atom, and the like; Rrepresents &#x2014;C(&#x2550;O)NRR(wherein Rand Rmay be the same or different, and each represents a hydrogen atom, and the like), and the like; Lrepresents &#x2014;CRR&#x2014; (wherein Rand Rmay be the same or different, and each represents a hydrogen atom, and the like), and the like; and Wand Wmay be the same or different, and each represents C&#x2014;R(wherein Rrepresents a hydrogen atom, and the like), and the like. 

Ring-fused heterocyclic derivative

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Tokyo, Japan

Tomohiro Danjo