Daicel Chemical Industries, Ltd.

Director-general of Agency of Industrial Science and Technology

Director General Agency of Industrial Science and Technology

Tomohiko Yamaguchi

Toshio Shinbo

Kouzou Tachibana

Masaaki Sugiura

A crown ether compound is shown below and useful as a separating agent for chemical compounds. ##STR1## (In the formula, A and B represent hydrogen atoms, straight chain or branched alkyl groups having 1-6 carbon atoms, allyl groups having 6-10 carbon atoms, or aralkyl groups having 7-9 carbon atoms. Although A and B may be different groups, it is preferable that they be the same. R.sub.1 represents a hydrogen atom, a straight chain or branched alkyl group having 1-20 carbon atoms, or preferably an alkyl group having 6-16 carbon atoms. R.sub.1 may be bonded to any carbon atom on the cyclical ester group and its number is 1-12, and preferably 1-3. n represents an integer from 3-10, and preferably 4-8, with 5 or 6 being even more preferable. In addition R.sub.2 and R.sub.3 represent straight chain or branched alkyl groups having 1-30, and preferably 6-20 carbon atoms, or aryl groups having 6-18 carbon atoms, or aralkyl groups having 7-30 carbon atoms. The location of R.sub.2 and R.sub.3 may be anywhere other than the A and B substitution positions on the condensed ring, and although one of each of R.sub.2 and R.sub.3 is satisfactory, a maximum of 5 groups may be substituted. In addition, R.sub.2 and R.sub.3 may also be different.)

Crown ether compound and separating agent

A filler for separating an optical isomer comprising a surface-hydrophobic filler component and an optically active lipophilic crown compound carried on the filler component by adsorption. The filler may be charged in a column to carry out separation of a sample such as amino acid or the like in the form of an aqueous solution.

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Dortmund, Germany

Tomohiko Yamaguchi