Toray Industries, Inc.

Tomohiko Suzuki

Toshiaki Tanaka

Kuniaki Kawamura

Yoshitaka Yoshizawa

Hiroshi Nagase

Takashi Endo

Kimiyasu Shiraki

Hideaki Inada

Tsutomu Suzuki

Kazumi Nishimura

Mikito Hirakata

Yasushi Kuraishi

Kanako Serizawa

Tatsuya Nishi

Yoshitake Yoshizawa

A method of inhibiting a rise in intraneuronal calcium concentration includes administering an effective amount of a cyclic amine derivative represented by formula (I) or a pharmacologically acceptable salt thereof to a subject in need thereof: wherein A represents formula (IIa), (IIb) or (IIc): 

Agent for inhibiting rise in intraneuronal calcium concentration

A therapeutic or prophylactic agent for cachexia includes as an effective ingredient a compound having a specified morphinan skeleton represented by a compound of the following structure: or a pharmacologically acceptable acid addition salt thereof.

Therapeutic or prophylactic agent for cachexia

The present invention relates to a therapeutic agent for neuropathic pain containing, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof: (wherein R, R, R, R, R, R, R, R, A, and B have the same definitions as those described in the specification), and an animal model produced by administering (+)-4a-(3-hydroxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octohydro-trans-quinolino[2,3-g]isoquinoline. The present invention makes it possible to perform drug treatment for neuropathic pain. The therapeutic effect of a compound against neuropathic pain can also be evaluated.

Remedies for neuropathic pain and model animals of neuropathic pain

A therapeutic agent for sepsis and various symptoms accompanying sepsis (such as septic shock, disseminated intravascular coagulation syndrome, adult respiratory distress syndrome and multiple organ dysfunction) is disclosed. The therapeutic agent for sepsis according to the present invention comprises as an effective ingredient an opioid &#x3ba; receptor agonist compound such as (&#x2212;)-17-(cyclopropylmethyl)-3,14&#x3b2;-dihydroxy-4,5&#x3b1;-epoxy-6&#x3b2;[N-methyl-trans-3-(3-furyl)acrylamide] oxide derivative. The opioid &#x3ba; receptor agonist compound may be administered as it is or in the form of a pharmaceutical composition prepared by mixing the compound with a known pharmaceutically acceptable acid, carrier or vehicle orally or parenterally.

Remedies for sepsis

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Kamakura, Japan

Tomohiko Suzuki