Yoshitomi Pharmaceutical Industries, Ltd.

Tomohiko Munakata

Kazuhiro Goto

Yoshifumi Ikeda

Yutaka Maruyama

Kazumi Saeki

Chiaki Tashiro

Hideo Matsuki

Junichi Sakai

Katsuyoshi Isagai

Kiyoteru Ikegami

Antibiotics Y-16482 .alpha. and/or Y-16482 .beta., a process for

A polycondensation product of a germanium trihydroxide compound of the formula: ##STR1## wherein W is hydrogen, alkyl, halogen, alkoxycarbonyl, carboxy, aryl, cycloalkyl which may be substituted, cycloalkenyl, heteroaryl or a group of the formula: (R.sup.1)(R.sup.2)N-- wherein R.sup.1 and R.sup.2 are each lower alkyl or R.sup.1 and R.sup.2 together with the adjacent nitrogen atom form a group of the formula: ##STR2## wherein R.sup.3 is hydrogen, lower alkyl, phenyl which may be substituted, aralkyl, acyl, acylamino or heteroaryl, and X is --N.dbd., --CH.dbd. or ##STR3## A is a bond, alkylene, alkenylene, --CO--Y--, --CONH--Y--, --O--Y--, --S--Y-- or ##STR4## (Y is alkylene); and R is alkyl. Such compounds are useful as agents for treating immune diseases.

Organogermanium compounds

A heterocyclic compound of the formula: ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein R.sup.1 is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxycarbonyl, formyl, nitroso, acyl, phenacyl, aralkyl, .alpha.-(benzyloxycarbonyl)benzyl or .alpha.-carboxybenzyl; each of R.sup.2 and R.sup.3 is hydrogen, C.sub.1-4 alkyl or aryl; and all of R.sup.4, R.sup.5 and R.sup.6 are hydrogens, or both R.sup.1 and R.sup.6, and R.sup.4 and R.sup.5 together form single bonds; in which definitions the term 'acyl', 'phenacyl', 'aralkyl' or 'aryl' means that it may be substituted by at least one substituent at any position(s) on the aromatic nucleus, each substituent being independently selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, hydroxyl, phenyl, nitro, trifluoromethyl, methylthio, methanesulfonyl and methylenedioxy. Such compounds are useful as drugs for treating immune diseases.

Imidazo[2',1':2,3]-thiazolo[5,4-c]pyridines and composition thereof for

Growing community of inventors

Nakatsu, Japan

Tomohiko Munakata