The Broad Institute, Inc.

Variagenics, Inc.

Massachusetts General Hospital Corporation

The General Hospital Corporation

The Brigham and Women's Hospital, Inc.

Sequenom, Inc.

Other

The Board Institute, Inc.

Tomohiko Kawate

Jia Liu Wolfe

Gregory Lawrence Verdine

Vincent P Stanton, Jr

Deborah Hung

Sarah Stanley

Motohisa Shimizu

Charles Allerson

Noriakie Iwase

Jeffrey Charles Olson

Sarah Grant

Vince P Stanton, Jr

Benito Munoz

Michael H Serrano-Wu

Timothy A Lewis

Sivaraman Dandapani

Partha Pratim Nag

Noriaki Iwase

Colin W Dykes

The invention relates to compounds of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof: 

Compounds for the treatment of mycobacterial infections

The invention relates to compounds of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof:

Disclosed are compounds that can be used for treating tuberculosis.

Compounds for the treatment of tuberculosis

Disclosed ore substituted aminothiazoles, which can be used for, among other things, the treatment of tuberculosis, pharmaceutical compositions containing the same, and methods of using the same.

Substituted aminothiazoles for the treatment of tuberculosis

The present invention relates to methods for the detection of polymorphisms by substituting a base-modified nucleotide for a natural nucleotide in a polynucleotide. The base-modified nucleotide renders the polynucleotide more susceptible to cleavage at the sites of its incorporation than site consisting of natural nucleotides. The fragments obtained are then analyzed to determine the presence or absence of a polymorphism.

Base-modified nucleotides and their use for polymorphism detection

The present invention relates to a method for genotyping a diploid organism to detect single nucleotide polymorphisms (SNPs) using modified nucleotides or nucleotide residues substituted with fluorescent groups.

Fluorescence-based genotyping

The present invention relates to methods for the detection of polymorphism in polynucleotides by using hybridization of fragments of segments of a polynucleotide suspected of containing a polymorphism with an oligonucleotide having a sequence complementary to a fragment identifying the polymorphism and subsequent detection of incorporated labels in the oligonucleotide-fragment duplex.

Method for identifying polymorphisms

The present invention is directed to novel base-modified nucleotides and methods for their use in the preparation and cleavage of modified polynucleotides.

Base-modified nucleotides and cleavage of polynucleotides incorporating them

The present invention relates to a method of synthesizing a polynucleotide with incorporation of a modified nucleotide.

Method for analyzing polynucleotides

The present invention relates to methods for the analysis of polynucleotides including detection of variance in nucleotide sequence without the need for full sequence determination, full sequence determination of a polynucleotide, genotyping of DNA and labeling a polynucleotide fragment during the process of cleaving it into fragments.

Growing community of inventors

Cambridge, MA, United States of America

Tomohiko Kawate