Other

Tobishi Yakuhin Kogyo Kabushiki Kaisha

Tomohiko Ishikawa

Tsutomu Inoue

Takashi Inaba

Hiroyoshi Hidaka

Tadashi Morita

Osamu Sakuma

Masayuki Yuasa

Masatoshi Hagiwara

Isao Umezawa

Tadashi Toshioka

Kenji Naitoh

Horoyoshi Hidaka

Kenji Naito

Shinpei Kidokoro

An anti-ulcer agent contains a compound expressed by the following general formula 1: ##STR1## where, R.sub.1 is hydrogen atom or an alkyl group having 1 or 2 carbon atoms with or without substitution, R.sub.2 and R.sub.3 are resp. hydrogen atom or form oxo group together, R.sub.4 is hydrogen atom or methyl group or isoquinoline sulfonyl group, n is 2 or 3, A is N--R.sub.5 or CH--R.sub.5, R.sub.5 is phenyl group with or without substitution or benzyloxycarbonyl group with or without substitution, or a physiologically allowable acid added salt thereof as the active component.

Anti-ulcer agent

Novel quinoline sulfonamino derivatives having a vessel smooth muscle relaxation activity as well as a platelet agglutination inhibitory activity and inhibitory activity to protein kinase A, myosin light chain kinase, proteinkinase C, and calmodulindependent proteinkinase II, but having little action or cardio function; a process for the production of the derivatives, and a pharmaceutical composition containing the derivative.

Compound having vessel smooth muscle relaxation activity

Derivatives of isoquinoline (and naphthalene) sulfonamides

Novel compounds represented by the formula: ##STR1## wherein R.sub.1 represents an alkyl group having 1 to 3 carbon atoms, R.sub.2 represents an amino group or a group of formula ##STR2## in which R.sub.4 represents an alkyl group having 1 to 3 carbon atoms, R.sub.5 represents an alkyl group having 1 to 3 carbon atoms or may combine with R.sub.6 to form a five or six membered ring containing 4 to 5 carbon atoms, R.sub.6 represents a hydrogen atom or may combine with R.sub.5 to form a five or six membered ring containing 4 to 5 carbon atoms, R.sub.3 represents a hydrogen atom, an alkyl group having 1 to 3 carbon atoms or a halogen atom, X represents a carbonyl group or a methylene group, Y represents a sulfur atom or a vinylene group and pharmaceutically acceptable salts thereof which exhibit a vasodilating activity and inhibitory activity for platelet aggregation. Thus, they are useful as therapeutic agents for treatment of angina pectoris, hypertension, throbosis and the like.

Novel compounds exhibiting a vasodilating activity and inhibitory

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Nagoya, Japan

Tomohiko Ishikawa