Eisai Company, Limited

Tomohide Tanaka

Hideaki Watanabe

Yutaka Morita

Yoshio Tanabe

Yasushi Ishihama

Akio Imai

Shigemitsu Osawa

Kana Satoh

Akiyo Ohtsuka

Itaru Sakai

Takashi Kajima

Takashi Hibi

Yasushi Tomita

Yukio Narabu

Donepezil hydrochloride, 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride, is provided here in the form of four polymorphs which are stable against heat and humidity in the pharmaceutical use. They can be industrially produced. They are specified by peaks in X-ray powder diffraction pattern and absorption peaks in infrared absorption spectra in potassium bromide.

Polymorphs of donepezil hydrochloride and process for production

A whitening embellisher includes, as an active ingredient, teprenone (chemical name: geranylgeranyl-acetone). A whitening and beautifying composition includes teprenone and one or more substances selected from kojic acid, L-ascorbic acid and the like. The whitening embellisher, and whitening and beautifying composition prevent the skin from pigmenting and darkening due to sunburn and/or aging, and quicken fading, and hence make spots and freckles inconspicuous when the preparations are used for external application as a cream or milky lotion.

Whitening embellisher

A whitening embellisher includes, as an active ingredient, teprenone (chemical name: geranylgeranylacetone). A whitening and beautifying composition includes teprenone and one or more substances selected from kojic acid, L-ascorbic acid and the like. The whitening embellisher, and whitening and beautifying composition prevent the skin from pigmenting and darkening due to sunburn and/or aging, and quicken fading, and hence make spots and freckles inconspicuous when the preparations are used for external application as a cream or milky lotion.

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Ibaraki, Japan

Tomohide Tanaka