Daiichi Sankyo Company, Limited

Tomoharu Tsukada

Takashi Suzuki

Koichi Nakamura

Makoto Mori

Noriyasu Haginoya

Masahiro Ota

Takeshi Jimbo

Katsuhiro Kobayashi

Miho Hayakawa

Yosuke Ando

Tsuyoshi Shinozuka

Kunihiko Fujii

The present disclosure provides novel compounds or salts thereof, or crystals of the compounds or the salts, which inhibit Axl and are useful in the treatment of a disease caused by hyperfunction of Axl, the treatment of a disease associated with hyperfunction of Axl, and/or the treatment of a disease involving hyperfunction of Axl. The present disclosure provides pyridone derivatives having a tetrahydropyranylmethyl group represented by the following formula (I) having various substituents, or salts thereof, or crystals of the compounds or the salts, wherein R, R, R, R, R, W, X, Y, and Z are each as defined in the specification: 

Pyridone derivatives having tetrahydropyranylmethyl groups

The present invention relates to a novel pyridine derivative or a pharmacologically acceptable ester thereof, or a pharmacologically acceptable salt of the derivative or ester, which has an excellent hypoglycemic effect or treats and/or prevents the onset of a disorder of carbohydrate or lipid metabolism or a disease mediated by peroxisome proliferator-activated receptor (PPAR) &#x3b3;. A compound represented by the general formula (I): [wherein R represents a pyridyl group substituted with 1 to 3 group(s) independently selected from Substituent Group A, and Substituent Group A represents a halogen atom, a C-Calkyl group and a C-Calkoxy group] or a pharmacologically acceptable ester thereof, or a pharmacologically acceptable salt of the compound or ester.

Pyridine derivative

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Tokyo, Japan

Tomoharu Tsukada