Dainippon Sumitomo Pharma Co., Ltd.

Tomoaki Nishida

Hidefumi Yoshinaga

Tomohiro Toyoda

Provided is a new serotonin-reuptake inhibitor that exhibits affinity for serotonin-1A receptors. Said serotonin-reuptake inhibitor is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. In the formula, Rrepresents a hydrogen atom, a 2-hydroxyethyl group, or a 2-methoxyethyl group. Rrepresents one of the following bonded to a methylene group which is bonded to a piperidine ring: a chlorine atom bonded in a p-position; a bromine atom bonded in a p-position; a methyl group bonded in a p-position; a chlorine atom bonded in an m-position; or a bromine atom bonded in an m-position. Either Yrepresents a hydrogen atom and Yrepresents a hydrogen atom or a hydroxyl group, or Yand Ytogether represent an oxo group. Z represents a group represented by one of the following formulas: formula (3-1-1), formula (3-1-2), formula (3-2-1), formula (3-2-2), formula (3-3-1), formula (3-3-2), formula (3-4-1), or formula (3-4-2). However, if Rrepresents a 2-hydroxyethyl group or a 2-methoxyethyl group and Yand Yboth simultaneously represent hydrogen atoms, then Z represents a group represented by one of the following formulas: formula (3-1-2), formula (3-2-1), formula (3-2-2), formula (3-3-1), formula (3-3-2), formula (3-4-1), or formula (3-4-2). 

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Osaka, Japan

Tomoaki Nishida