Kyowa Hakko Kogyo Co., Ltd.

Tomoaki Masada

Eiji Hayakawa

Yasuhiko Ueno

Kiyoshi Morimoto

Yasushi Watanabe

Shunji Ichikawa

Katsuichi Shuto

Yorozu Yokomori

Toshikazu Murayama

Tokuyuki Kuroda

Motohiro Ohta

Teiichi Miwa

Yoshika Sanada

Makoto Kigoshi

Yasuhiro Ishikawa

Masaki Azuma

Yoshio Yumiba

Mitsuru Terajima

Hirotake Naganuma

The present invention relates to a solid dispersion and a solid dispersion dosage form which comprise a xanthine derivative represented by the following formula (I) or a pharmacologically allowable salt thereof and a polymer.

Solid dispersion dosage form of amorphous xanthine derivative and enteric-coating polymer

A rotary-type tabletting machine with lubricant spraying means, wherein a turn table has plural penetrated holes comprising dies provided at fixed intervals in a ring-like arrangement, each hole is provided with a pair of punches above and under the hole, each pair of punches is rotated together with the turn table and execute piston operation so that tablets are continuously produced by compressing pharmaceutical material filled in the die. The rotary-type tabletting machine is provided with a spraying chamber with an upper open end for inserting an upper punch and enclosing the die when the turn table moves to a rotation position which is after a rotation position where a molded table is discharged and before a rotation position where pharmaceutical material is filled in the die. A spray connected with the spraying chamber sprays lubricant in the spraying chamber, and pulsating air generating means connected with the spraying chamber diffuses. The lubricant sprayed in the spraying chamber.

Rotary-type tabletting machine with lubricant spraying means

Disclosed is a process for producing a composition for ruminants, which is characterized in that a nucleus containing a physiologically active substance is coated with a coating material prepared by suspending in water (i) an emulsion comprising water and at least one hydrophobic substance hardly soluble in water and (ii) a slurry containing at least one polymer soluble in water of pH 5.0 or below and insoluble in water of pH over 5.0 In the process, an aqueous suspension is used for coating instead of a meterial dissolved in an organic solvent.

Process for producing compositions for ruminants

A motilin preparation in the form of a rectal suppository containing motilin together with a pH controller capable of adjusting the pH value of the intrarectal fluid to 8.0 to 10.0, which is highly useful as a rectal suppository.

Rectal motilin preparation

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Mishima, Japan

Tomoaki Masada