Stanley Electric Co., Ltd

Astellas Pharma Gmbh

Hitachi Cable, Inc.

Tomoaki Abe

Gen Murakami

Akira Suga

Toru Watanabe

Takanori Koike

Ryushi Seo

Keizo Sugasawa

Susumu Yamaki

Itsuro Shimada

Kenichi Kawaguchi

Hidenori Azami

Shunichiro Matsumoto

Dai Aoki

Kazushi Watanabe

Takahiro Nigawara

Tetsuya Saito

Tomoyoshi Imaizumi

Kaori Namioka

Kazuyuki Kuramoto

Shigeki Kunikawa

Michinori Akaiwa

Takashi Shin

Keisuke Arakawa

Toshiaki Morikawa

Takanobu Araki

Yoshiki Satake

Masayuki Tanahashi

Masashi Shimazaki

Atsushi Otaka

Hironori Harada

Takaho Nomura

Takaho Matsuzawa

[Problem] Provided is a compound which is useful as an active ingredient of a pharmaceutical composition for treating lung cancer. [Means for Solution] The present inventors have studied a compound useful as an active ingredient of a pharmaceutical composition for treating lung cancer, and as a result, it was found that a quinazoline compound has an excellent G12C mutation KRAS inhibitory activity, and which can be used as a therapeutic agent for lung cancer, and thereby the present invention has been completed. The quinazoline compound of the present invention and a salt thereof may be used as the therapeutic agent for lung cancer.

Quinazoline compound

A ceramic multi-layered interconnection substrate can be manufactured by using a stack including a plurality of ceramic layers with division grooves in the uppermost layer, at least one intermediate layer, and the lowermost layer. The substrate can be manufactured by forming division grooves in respective green sheets other than the uppermost and lowermost ones at adjacent package boundaries, pressing them to be stacked, forming division grooves in the uppermost and lowermost sheets at the adjacent package boundaries, firing them to be ceramic layers, and breaking the ceramic layers along the division grooves to separate individual packages, thus preventing failure and preventing the generation of burrs, chips, and the like.

Method for manufacturing ceramic multi-layered interconnection substrate

[Object] To provide a therapeutic and/or prophylactic agent for urinary frequency, urinary urgency, and urinary incontinence associated with various lower urinary tract diseases including overactive bladder, various lower urinary tract diseases accompanied by lower urinary tract pain, such as interstitial cystitis, chronic prostatitis, and the like, and various diseases accompanied by pain, based on an excellent trkA receptor inhibitory action. [Means for Solution] A novel azolecarboxamide compound in which a thiazole ring or an oxazole ring is bonded to a benzene ring, a pyridine ring, a pyridazine ring, a thiophene ring, a pyrazole ring or a pyrrole ring through carboxamide, or a salt thereof is confirmed to have a potent trkA receptor inhibitory activity, and found to be capable of being used as a therapeutic and/or prophylactic agent which is excellent in efficacy and safety for urinary frequency, urinary urgency, and urinary incontinence associated with various lower urinary tract diseases including overactive bladder, various lower urinary tract diseases accompanied by lower urinary tract pain, such as interstitial cystitis, chronic prostatitis, and the like, and various diseases accompanied by pain, thereby completing the present invention.

Azolecarboxamide compound or salt thereof

Provided is an agent for treating or preventing urinary frequency, urinary urgency and urinary, incontinence which are associated with overactive bladder, a lower urinary tract disease such as interstitial cystitis and chronic prostatitis accompanied by lower urinary tract pain, and various diseases accompanied by pain. A novel azolecarboxamide derivative in which an azole ring such as thioazole or oxazole is bonded to a benzene ring, pyridine ring or pyrimidine ring through carboxamide was confirmed to have a potent trkA receptor-inhibitory activity and found to be an agent for treating or preventing lower urinary tract disease and various diseases accompanied by pain, which is excellent in efficacy and safety, and thus the present invention was accomplished.

Azolecarboxamide derivative

A surface mount type light-emitting unit includes a light-emitting device. A first lead is connected electrically to a first electrode of the light-emitting device. A second lead is connected electrically to a second electrodc of the light-emitting device. A clear insulator seals the light-emitting device, a section connecting the first electrode to the first lead and a section connecting the second electrode to the second lead. An end of the first lead, forming a reflecting section, is molded into a cup-shaped portion having a flat bottom. The light-emitting device is bonded to the flat bottom. A surface of the reflecting section opposed to the flat bottom is exposed to a surface of thc insulator.

Light-emitting unit and method for producing same as well as lead frame used for producing light-emitting unit

A light-emitting diode for large current driving () is provided according to the invention. It comprises a metal substrate () having an upper surface and provided with an electrically insulated distribution circuit () formed on the upper surface. A metal base () is directly attached to the metal substrate () and provided with an LED chip () mounted thereon. A gold wire () is arranged to connect the distribution circuit to the LED chip. A resin lens () is arranged to cover part of the metal base over the LED chip including at least the gold wire (). Therefore, the metal base with the LED chip mounted thereon and the metal substrate can contact the atmosphere in a large area to dissipate heat efficiently. While keeping this construction, the LED chip can be wired with a small amount of heat through the distribution circuit separated from the metal substrate.

Light-emitting diode for large current driving

A surface mount type light-emitting unit composed of a light-emitting device, a first lead connected electrically with a first electrode of the light-emitting device, a second lead connected electrically with a second electrode of the light-emitting device, and a clear insulator for sealing the light-emitting device, a connecting section of the first electrode of the light-emitting device and the first lead, and a connecting section of the second electrode of the light-emitting device and the second lead wherein connecting terminal sections of the first and second leads for connecting them with external devices, respectively, are placed on a surface of the insulator, comprises an end of the first lead being molded into a cup-shaped portion having a flat bottom; the light-emitting device being bonded to the bottom inside a reflecting section corresponding to the molded cup-shaped portion of the first lead; and a surface opposed to that of the reflecting section on which the light-emitting device has been bonded being exposed to the surface of the insulator.

Growing community of inventors

Tokyo, Japan

Tomoaki Abe