Meiji Seika Kaisha, Ltd.

Tomizo Niwa

Takashi Shomura

Norio Ezaki

Shigeharu Inouye

Yujiro Yamada

Tatsuo Ito

Taro Niida

Michio Kojima

Jiro Itoh

Hitoshi Goi

Shinji Miyadoh

Yasuaki Ogawa

Chuhei Nojiri

Shoichi Amano

Shinji Miyado

Akira Suzuki

Takashi Tsuruoka

Masaji Sezaki

Shigeo Seki

Shoji Omoto

Fumio Kai

Kazunori Ohba

Tetsutaro Niizato

Harumi Fukuyasu

Yuzo Kazuno

Kazuo Saito, Deceased

Mitsugu Itoh

Kazuo Saito

Kunikazu Totsugawa

Saeko Takahashi

Kazunori Oba

Disclosed is an antiviral agent comprising as an active component a substance SF-2140 described in detail in the specification, and a pharmaceutically acceptable carrier. Also disclosed is a method for treatment of viral diseases comprising administering a pharmaceutically effective amount of the substance SF-2140.

Antiviral agents

An antibiotic SF-2103A substance or a salt thereof, and a process for the production thereof are described, and the process comprises cultivating an antibiotic SF-2103A substance-producing strain in a nutrient medium and recovering the desired substance from the culture broth.

Antibiotic SF-2103A substance and process for production thereof

Disclosed is a novel antibiotic SF-2107 series substance consisting essentially of Substance SF-2107 A-1, Substance SF-2107 B and/or Substance SF-2107 C, each having the phisico-chemical properties as described in the specification, which substance exhibits an antibacterial activity against both gram-positive and gram-negative bacteria and is useful for pharmaceuticals, bactericides, disinfectants, etc. Also disclosed is a process for preparing the substance.

Novel antibiotic SF-2107 series substance and process for preparing the

Antibiotics, designated as SF-2080A substance and SF-2080B substance, are described, and are obtained by cultivating an SF-2080 substance-producing strain belonging to the genus Streptomyces, for example, Streptomyces sp. SF-2080 (FERM-P No. 5072, ATCC No. 31673), in a nutrient medium, and recovering the desired substance from the culture.

Antibiotic substances and processes for production thereof

A new antibiotic SF-1130-x.sub.3 substance is produced by cultivating a microorganism Streptomyces myxogenes SF-1130 (deposited under FERM-P. 676 and ATCC 31305) in a liquid culture medium under aerobic conditions, and this antibiotic may be isolated from the fermentation broth of said microorganism and is useful as an inhibitor to .alpha.-glucosidase and saccharase. Besides, this antibiotic, when orally given, is useful as a drug for suppressing an elevation in the level of blood sugar in living animals which have taken starch and/or sugars.

Antibiotic SF-1130-x.sub.3 3 substance and production and use thereof

A novel antibiotic BN-235 substance and a process for making it are described, wherein the hydrochloride thereof has the following properties:

Novel antibiotic BN-235 substance, and process for the production thereof

A BN-213 substance-producing strain of the genus Pseudomonas is cultivated to produce BN-213 substance in a culture medium. The BN-213 substance is isolated from the culture medium and purified, and proved to be a novel antibiotic.

Novel antibiotic BN-213 substance and its production

L-2-Amino-4-methylphosphinobutyric acid (L-MPGA) which is useful as bactericide and herbicide can be prepared by optical resolution of its racemic mixture, D,L-MPGA with the action of a microbial acylase. The process comprises providing D,L-MPGA in the form of its N-acyl derivative, reacting N-acyl-D,L-MPGA in an aqueous medium with a microbial acylase having an optically specific hydrolytic activity, whereby selectively eliminating the acyl group of N-acyl-L-MPGA to give a mixture of L-MPGA and N-acyl-D-MPGA and isolating L-MPGA from the mixture. The acylase is produced by cultivating a microbial strain belonging to the genus Pseudomonas, Streptomyces or Aspergillus, particularly Pseudomonas maltophilia BN-233, Streptomyces violascens SF 2072, Streptomyces diastatochromogenes SF 2073, Aspergillus sp. KS-101 or Aspergillus sp. KS-102.

Process for the optical resolution of

New antibiotics, SF-2050 substance and SF-2050B substance are produced by cultivating a microorganism Streptomyces sp. SF-2050 now deposited under FERM-P 4358 and under ATCC. 31450 in a liquid culture medium under aerobic conditions, and these antibiotics may be isolated from the fermentation broth and useful as an antibacterial agent. These antibiotics have an activity inhibitory to .beta.-lactamase.

Antibiotics SF-2050 and SF-2050B substances and production and use

Compounds are provided having the general formula I: ##STR1## wherein X represents an hydroxyl group, an acetoxy group or a thiosulfuric acid residue. The formula I compounds are prepared from compounds of the general formula II: ##STR2## wherein R.sub.1 represents hydrogen, a lower alkanoyl group, an arylalkanoyl group, an alkoxycarbonyl group, a lower haloalkoxycarbonyl group, a substituted or unsubstituted aroyl group, a N-arylcarbamoyl group of a substituted or unsubstituted aryl group; R.sub.2 either represents hydrogen or, together with the ##STR3## group, represents a phthalimido group; and X represents an hydroxyl group, an acetoxy group or a thiosulfuric acid residue, or their metal salts or their salts with organic bases, by causing the culture of a cephalosporin C acylase-producing strain of a microorganism, especially a mold, fungus, or the secondary preparation therefrom, to act on the latter compounds II in the presence of an aqueous medium.

Process for the preparation of 7-amino-cephem compounds using mold fungi

Novel 7-(5-amino-5-carboxyvaleramido)-7-methoxy-3-hydroxymethyl-3-cephem-4-carbo xylic acid derivatives. Such derivatives are prepared by subjecting cephamycin type compounds to the action of esterase enzyme of mold fungi.

Process for the production of cephamycin type antibiotic substances

D-Gluconic-.delta.-lactam is obtained by oxidizing nojirimycin with glucose-oxidizing enzymes or by the action of microorganisms capable of producing glucose-oxidizing enzymes.

Growing community of inventors

Yokohama, Japan

Tomizo Niwa