Progen Pharmaceuticals, Inc.

Progen Pg500 Series Pty Ltd

Tomislav Karoli

Vito Ferro

Ligong Liu

Paul Newton Handley

Kenneth David Johnstone

Norbert Wimmer

Edward Timothy Hammond

Jon Krueger Fairweather

The invention relates to novel compounds that have utility as inhibitors of heparan sulfate-binding proteins; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment of a mammalian subject.

Sulfated oligosaccharide derivatives

The invention relates to compounds which are polysulfated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase; methods for the preparation of the compounds; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment, lowering of blood triglyceride levels and inhibition of cardiovascular disease of a mammalian subject.

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Kenmore, Australia

Tomislav Karoli