University of Washington

Tomikazu Sasaki

Narendra Pal Singh

Henry C Lai

Keith B Elkon

Jie An

Mark Minie

Joshua J Woodward

Shusheng Wang

Henry Chiu-Yuen Lai

Steve J Oh

The present invention provides therapeutic strategies for treatment of severe debilitating diseases associated with IFN-I due to cGAS activation. In one aspect, the invention provides compounds of Formula (I): [Formula should be inserted here] and pharmaceutical uses thereof. In another aspect, the invention provides methods for treating an autoimmune disease or a monogenic disorder by administering an effective amount of a compound of Formula (I). 

CGAS in systemic lupus erythematosus (SLE)

The present disclosure describes artemisinin compounds. The compounds can be synthesized using an Ugi synthesis reaction and can be used in the treatment of cancers, parasitic infections and yeast infections.

Artemisinin compounds and synthesis and use thereof

The invention relates to covalent conjugates between endoperoxides and small peptides and organic compounds that bind to molecular cavities on the transferrin or lactoferrin receptor, and the use of compositions comprising these conjugates to treat cancer, hyperproliferative disorders, inflammatory diseases, and infections.

Covalent conjugates between endoperoxides and transferrin and lactoferrin receptor-binding agents

In one aspect, the invention provides covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins. In some embodiments, the covalent conjugates comprise artelinate and holotransferrin. In another aspect, the invention provides methods for administering the covalent conjugates of the invention to treat cancer and infections by pathogens that bind iron-carrying proteins.

Covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins and methods of use

Compounds having an artemisinin-related endoperoxide moiety covalently coupled to a hydrazone moiety through a linker. Compositions and methods for treating cancer using the compounds.

Growing community of inventors

Bothell, WA, United States of America

Tomikazu Sasaki