Btg International Limited

Tomiichiro Oda

Shigeko Uryu

Shinya Tokuhiro

Kazuo Koyama

Isao Kaneko

Shinji Marumoto

Masaki Meguro

Method for treating Alzheimer's disease, Parkinson's disease, Huntington's chorea or Pick's disease by administering to a patient a compound of formula (I) wherein Rrepresents hydrogen; Rrepresents hydrogen, a C-Calkyl group or C-Ccycloalkyl group; A represents nitrogen; D represents a methylene group, a methyl methylene group, a halogen atom substituted methylene group or a halogen substituted methyl methylene group; E represents CH, CHRwherein Rrepresents a C-Calkyl group, CH or a carbon atom substituted by a C-Calkyl group; Arom represents aryl, aryl having from 1 to 3 identical or different substituent groups selected from halogen, C-Calkyl, and C-Calkyloxy, heteroaryl or heteroaryl having from 1 to 3 substituent groups, selected from halogen, C-Calkyl and C-Calkyloxy. The part represented byis a single bond or double bond.

Medicine containing pyrimidine derivative

Pharmaceutical compositions and methods of treatment are provided for treating amyloidosis, containing, as an active ingredient, at least one nitrogen-containing heteroaryl compound represented by the following general formula or a pharmacologically permitted salt thereof; together with nitrogen-containing heteroaryl derivatives, and pharmacologically permitted salts thereof: 

Preventives or remedies for alzheimer's disease, or amyloid protein fibril-formation inhibitors, which include a nitrogen-containing heteroaryl compound

A medicine for central diseases which contains as the active ingredient either a compound represented by the general formula (I): (I) (wherein Rrepresents hydrogen or Calkyl; Rrepresents Calkyl, etc.; A represents carbon, etc.; D represents Calkylene, etc.; E represents carbon, etc.; and Arom represents aryl, etc.) or a pharmacologically acceptable salt of the compound. 

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Tokyo-to, Japan

Tomiichiro Oda