Yamanouchi Pharmaceutical Company Ltd.

Merck Patent Gesellschaft MIT Beschrankter Haftung

Tomihisa Kawasaki

Yuzo Matsumoto

Isao Yanagisawa

Seiji Kaku

Hiroyuki Koshio

Fukushi Hirayama

Seijiro Akamatsu

Masato Ichihara

Tsukasa Ishihara

Masashi Funatsu

Hexahydro-1,4-diazepine derivatives represented by general formula (I); pharmaceutically acceptable salts thereof; and drugs containing the same as the active ingredient, such as activated blood coagulation factor X inhibitor, wherein A: phenylene, pyridylene, or the like; B: a 5- or 6-membered aryl or heteroaryl ring; X: &mdash;CO&mdash;, &mdash;CONH&mdash;, &mdash;CSNH&mdash;, &mdash;SO,&mdash;, &mdash;SO,NH&mdash;, or the like; Y: a bond or alkylene; R,: hydrogen, alkyl, &mdash;Y&mdash;(hetero) aryl, or the like; R,: hydrogen, alkoxy, &mdash;COOH, or the like; R,: amidino or a group capable of being converted into amidino; and R,, R,: each independently hydrogen or lower alkyl.

Hexahydro-1,4-diazepine derivatives or salts thereof

Substituted amidinobenzene derivatives and medicinal compositions thereof

Amidinonaphthyl derivative or salt thereof

Benzamidine derivatives and pharmaceutical composition containing them

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Tsukuba, Japan

Tomihisa Kawasaki