Kao Corporation

Kao Soap Company, Ltd.

Meito Sangyo Co., Ltd.

Tomihiro Kurosaki

Takashi Imamura

Junya Wakatsuki

Mitsuharu Masuda

Akira Matsunaga

Hiroshi Ito

Tohru Katoh

Shigeto Kayane

Shinichiro Omatsu

Nobutaka Horinishi

Hiroshi Kamitani

Masanobu Tanigaki

Haruya Kato

Hajime Hirota

Hiroki Sawada

Katsumi Kita

Hisao Tsutsumi

Toshio Nozaki

Junichi Fukasawa

Jun Kamegai

Yasuo Ishii

Tomohiko Sano

Akira Tsunoda

Takashi Kawai

Yoshitaka Kokusho

Hidekazu Ogino

Shigeaki Kato

Hisakazu Furugaki

Toshinao Ukena

Kiyoshi Aimono

Masaru Sakata

Akio Manba

Norio Nishikawa

Junko Kakuse

Mitsugu Morishita

Genji Imokawa

Makoto Hayashi

Fumimaro Sekine

Katsutoshi Kojima

Junya Watatsuki

Toru Kato

Norio Nishigawa

Motoru Takeda

Yoshiko Chikawa

Takashi Itoh

Noriko Inoue

A process for preparing glucose-1-phosphate from an .alpha.-glucan and orthophosphate using a phosphorylase immobilized onto an anion-exchange resin is disclosed. The anion-exchange resin used is a synthetic polymer resin into which an anion exchange group; a primary to quarternary ammonium group, a phosphonium group, or a sulfonium group, is introduced. This type of immobilized phosphorylase ensures (i) an effective utilization of phosphorylase, (ii) a higher reactivity of a higher absorbance of the phosphorylase to the resin, (iii) an excellent phosphorylase activity retention performance, and (iv) a higher physical strength of the resin.

Immobilized phosphorylase

An alkali metal monoalkylphosphate having a saturated or unsaturated straight-chain or branched hydrocarbon group having from 8 to 32 carbon atoms is described; also described is a process for preparing particles of said alkali metal zinc monoalkylphosphate and cosmetics containing said particles.

Alkali metal zinc monoalkylphosphate, particles thereof, process for

A novel monophosphate and a novel diphosphate prepared by a phosphatidyl transfer reaction of a phospholipid and an alcohol in the presence of phospholipase D are disclosed. The phosphates can independently or together form small and stable liposomes which can include active components therein. Cosmetic compositions comprising these phosphates or liposomes penetrate well into the hair and the skin, and exhibit long-lasting excellent moisture-retaining, beauty, skin-activation effects.

Phosphate, liposome comprising the phosphate as membrane constituent,

Phosphoric acid esters represented by the following formulae (I) and (IX) as well as processes for preparing them are disclosed. ##STR1## wherein R.sub.1 represents a linear or branched, alkyl or alkenyl group having a C.sub.1-36 carbon atom content, with or without the hydrogen atom(s) being substituted with fluorine atom(s), or a phenyl group with substituted linear or branched alkyl group(s) having a C.sub.1-15 carbon atom content, R.sub.2 represents an alkylene group having a C.sub.2-3 carbon atom content, R.sub.3 and R.sub.4 independently denote a hydrogen atom or an alkyl group having a C.sub.1-3 carbon atom content, R.sub.5 and R.sub.6 independently denote a hydrogen atom, or an alkyl, alkenyl, or phenyl group with or without the hydrogen atom(s) being substituted with group(s) containing hetero atom(s), excepting for a mercapto group, R.sub.7 and R.sub.8 independently denote a hydrogen atom, or an alkyl, or alkenyl group, m is an integer of 0-30, n is an integer of 0-5, l is an integer of 0-3, M is a hydrogen atom, an alkali metal, an alkali earth metal, an ammonium group, an alkyl amine group, or an alkanol amine group. The phosphoric acid esters have outstanding surface activity and good foaming capability, and imparts only extremely low irritation to the skin. The detergent composition into which they are formulated is particularly useful as, shampoo, baby shampoo, body shampoo.

Phosphoric acid ester, process for preparing the same, and detergent

A peptide or protein is modified by reacting a phosphoric acid ester represented by the following general formula (I) with a peptide or protein: ##STR1## wherein R.sub.1 means a linear or branched, C.sub.1-36 alkyl or C.sub.2-36 alkenyl group whose hydrogen atom or atoms may be substituted by the corresponding number of fluorine atom(s) or a phenyl group substituted by at least one linear or branched C.sub.1-15 alkyl group, R.sub.2 denotes a C.sub.2-3 alkylene group, m stands for a number of 0-30, and M is a hydrogen atom, an alkali metal ion, an alkaline earth metal ion, an ammonium ion, an alkylamine residue or an alkanolamine residue.

Modification method for peptides and proteins by reacting with a

A novel phosphoric ester of the formula (I) ##STR1## wherein, Z represents the following radicals ##STR2## useful as modifiers for amino acids, peptides and proteins which are easily decomposable in living bodies.

Phosphoric esters

Phosphoric acid esters represented by the following formulae (I) and (IX) as well as processes for preparing them are disclosed. ##STR1## wherein R.sub.1 represents a linear or branched, alkyl or alkenyl group having a C.sub.1-36 carbon atom content, with or without the hydrogen atom(s) being substituted with fluorine atom(s), or a phenyl group with substituted linear or branched alkyl group(s) having a C.sub.1-15 carbon atom content, R.sub.2 represents an alkylene group having a C.sub.2-3 carbon atom content, R.sub.3 and R.sub.4 independently denote a hydrogen atom or an alkyl group having a C.sub.1-3 carbon atom content, R.sub.5 and R.sub.6 independently denote a hydrogen atom, or an alkyl, alkenyl, or phenyl group with or without the hydrogen atom(s) being substituted with group(s) containing hetero atom(s), excepting for a mercapto group, R.sub.7 and R.sub.8 independently denote a hydrogen atom, or an alkyl, or alkenyl group, m is an integer of 0-30, n is an integer of 0-5, l is an integer of 0-3, M is a hydrogen atom, an alkali metal, an alkali earth metal, on ammonium group, an alkyl amine group, or an alkanol amine group. The phosphoric acid ester have outstanding surface activity and good foaming capability, and imparts only extremely low irritation to the skin. The detergent composition into which they are formulated is particularly useful as, shampoo, baby shampoo, body shampoo.

A novel phosphoric ester of the following formula (I) ##STR1## is prepared by reacting a phosphoric ester of the following formula (II) ##STR2## with a basic compound. By reacting the phosphoric ester (I) with various types of amine compounds or other acidic hydrogen-bearing compounds, various phospholipid analogue compounds or phosphoric esters can be derived.

Phosphoric esters and process for preparing the same

A detergent composition contains as an essential component a compound represented by the following general formula (I): ##STR1## wherein R means ##STR2## R.sup.1 denotes a straight-chain or branched alkyl or alkenyl group or a substituted phenyl group. R.sup.2 is an alkylene group having 2-3 carbon atoms, m is 0-30, and n stands for 0 or 1. M means a hydrogen atom or denotes an alkali metal, alkaline earth metal, zinc or aluminum atom, an ammonium ion, or an alkylamine or alkanolamine residuum thereby to indicate the formation of a salt of the compound of the general formula (I).

Detergent composition

Metal salts of monoalkyl phosphates of the following formula ##STR1## in which each R represents a saturated or unsaturated, linear or branched hydrocarbon group having from 8 to 32 carbon atoms, and M represents an alkaline earth metal or divalent transition metal. The metal salts are particularly suitable as cosmetic powders, fillers for resins, and lubricants, parting agents and pigment dispersants for polymeric compounds. When used as cosmetic powders, the metal salts improve spreadability, moistness, smoothness, adherence, transparency and covering power of cosmetics. Preparation process of the metal salts is also disclosed.

Metal salts of monoalkyl phosphates, preparation thereof, and cosmetic

A water-soluble viscosity increasing agent consisting essentially of: (i) an ester of a 40 to 400 moles ethylene oxide adduct of polyhydric alcohol and a C.sub.8-36 branched fatty acid, (ii) an ester of polyethylene glycol having average molecular weight of 2,000 to 20,000 and a C.sub.8-36 branched fatty acid, and (iii) a 40 to 400 mole ethylene oxide adduct of an ester of a polyhydric alcohol and a C.sub.8-36 branched fatty acid. The viscosity increasing agent can increase the viscosity of solutions of various surface active agents, while maintaining their stability and solubility in the solutions. When it is formulated to a detergent suitable for washing textiles, tablewares, human skins, hairs and the like, it can provide a detergent composition with a proper viscosity as well as a good detergency.

Water-soluble viscosity increasing agent and detergent composition

A novel method for purifying a sugar phosphate or its salt, in which a sugar-containing mixture of a sugar phosphate or its salt and phosphoric acid or its salt is subjected to electrodialysis to remove the phosphoric acid or its salt from the mixture. According to this method, the phosphoric acid or its salt can be readily obtained in a reusable form. The method is thus quite advantageous in view of the economy.

Method for purifying sugar phosphates or their salts

Novel phosphoric esters represented by the following general formula (I) ##STR1## wherein R.sub.1 represents a linear or branched alkyl or alkenyl group having 1 to 36 carbon atoms, or a phenyl group substituted with a linear or branched alkyl group having 1 to 15 carbon atoms, R.sub.2 represents an alkylene group having 2 to 3 carbon atoms, R.sub.3, R.sub.4 and R.sub.5 individually represent a hydrogen atom or a linear or branched alkyl group having 1 to 36 carbon atoms providing that any one of R.sub.3, R.sub.4 and R.sub.5 has 5 or more carbon atoms, and n is a number from 0 to 30 are obtained by reacting phosphoric esters of the following formula ##STR2## with amines at a high purity and in a high yield. The phosphoric esters (I) are excellent in the surface tension and foaming property, and give extremely low stimulus to the skin, so that they can be utilized in detergent compositions, cosmetic compositions, emulsifiers, dispersants, anti-static agents and the like.

Phosphoric ester

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Osaka, Japan

Tomihiro Kurosaki