Oy Jurilab Ltd.

Oy Juvantia Pharma Ltd.

Tomi-Pekka Tuomainen

Jukka T Salonen

Jari Kaikkonen

Marja Marchesani

Ullamari Pesonen

Markku Koulu

Matti Karvonen

Mika Scheinin

Paula Heinonen

Amir Snapir

Kristiina Nyyss&ouml;nen

Timo A Lakka

Riitta Salonen

Jussi Kauhanen

Pia Alhopuro

Veli-Pekka Valkonen

This invention is directed to a DNA sequence comprising a nucleotide sequence encoding a variant paraoxonase protein and to said variant paraoxonase protein as well as a method and a kit for detecting a risk of cancer, coronary or cerebrovascular disease, hypertension, type 2 diabetes, dementia, joint arthrosis, cataract, or sensitivity to organophosphorus compounds in a subject, the method comprising isolating genomic DNA from said subject, determining the allelic pattern for the codon 102 of the paraoxonase encoding PON1 gene in the genomic DNA, identification of Ile101Val mutation indicating said risk being increased and for targeting paraoxonase activity modulating therapies. Further this invention relates to transgenic animals comprising a human DNA molecule encoding said variant paraoxonase and to a method of phenotype-targeted gene sequencing.

DNA molecule encoding a variant paraoxonase and uses thereof

This invention relates to a DNA sequence comprising a nucleotide sequence encoding a variant &agr; -adrenoceptor protein and to the variant &agr; -adrenoceptor protein as well as a method for screening a subject to determine if the subject is a carrier of a variant gene that encodes the variant &agr; -adrenoceptor protein. Further this invention relates to a method for treating a mammal suffering from vascular contraction of coronary arteries, the method comprising the step of administering a selective &agr; -adrenoceptor antagonist to the mammal and to transgenic animals comprising a human DNA molecule encoding human &agr; -adrenoceptor protein or the variant &agr; -adrenoceptor protein.

DNA molecule encoding a variant &agr;2B-adrenoceptor protein, and uses thereof

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Kuopio, Finland

Tomi-Pekka Tuomainen