Rempex Pharmaceuticals, Inc.

Qpex Biopharma, Inc.

Schering-plough Animal Health Corporation

Intervet Inc.

Mpex Pharmaceuticals, Inc.

Essential Therapeutics, Inc.

Ilypsa, Inc.

Trine Pharmaceuticals, Inc.

Tomasz W Glinka

Scott J Hecker

Raja K Reddy

Olga Rodny

Maxim Totrov

Keith A Bostian

Olga Lomovskaya

Mark William Surber

Dale Edward Shuster

David Mark Wallace

Rajeshwar Singh

Brian Walter Eastman

Robert Higuchi

Dongxu Sun

Zhuoyi Su

Jason Zhang

Sunil V Pansare

Dominique Charmot

Aesop Cho

David C Griffith

Chi Ching Mak

Ving J Lee

Han-Ting Chang

Gavin C Hirst

Lee Shun Chong

Jerry M Buysse

Michael James Cope

Constantine G Boojamra

Jun Shao

Robert D Simmons

Neil Berkley

Elizabeth Goka

Chander Shekher Celly

Shiah-yun Chen

Trevor Calkins

Chun Chow

Damien Cartigny

Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs).

Boronic acid derivatives and therapeutic uses thereof

Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, &#x3b2;-lactamase inhibitors (BLIs).

Disclosed herein are antimicrobial compounds, compositions, pharmaceutical compositions, and the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.

Cyclic boronic acid ester derivatives and therapeutic uses thereof

Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents.

Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents. Other embodiments relate to pharmaceutical compositions containing boronic acid derivatives and additional excipient such as meglumine.

Disclosed herein are polybasic bacterial efflux pump inhibitors containing boronic acid functionality and their methods of synthesis, methods of use, and pharmaceutical compositions. Some embodiments include methods of treating or preventing a bacterial infection by co-administering to a subject infected with bacteria or at risk of infection with bacteria the efflux pump inhibitor with another anti-bacterial agent.

Boron containing polybasic bacterial efflux pump inhibitors and therapeutic uses thereof

The present invention relates to antimicrobial agents. Some embodiments include compounds, compositions, methods of preparation, and methods of treatment using new aminoglycosides and aminoglycoside derivatives.

Aminoglycoside derivatives

Disclosed are compounds having at least one quaternary alkyl ammonium functionality. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti-bacterial agent to treat or prevent bacterial infections. These combinations can be effective against bacterial infections that have developed resistance to anti-bacterial agents through an efflux pump mechanism.

Quaternary alkyl ammonium bacterial efflux pump inhibitors and therapeutic uses thereof

Growing community of inventors

Cuptertino, CA, United States of America

Tomasz W Glinka