Zoetis Services LLC

Tomasz Respondek

Richard Andrew Ewin

Todd M Maddux

Graham M Kyne

Mark R Cox

Paul D Johnson

Rajendran Vairagoundar

Michael P Curtis

Susan M K Sheehan

Matthew W Bedore

Timothy Lee Stuk

Imelda Hot

Govindan Subramanian

John Adam Wendt

Susan Mary Kult Sheehan

Christopher Scott Knauer

Jinxia (Nancy) Deng

Susan MK Sheehan

Jinxia Deng

Defined herein are immunomodulating Formula (1) compounds stereoisomers thereof, and pharmaceutically acceptable salts thereof; wherein R, R, R, R, W, Ring C and n are as defined herein, stereoisomers thereof, and pharmaceutically acceptable salts thereof; and compositions comprising said compounds. The invention also includes methods for treating an inflammatory and/or immunological disease or disorder in an animal by administering a therapeutically effective amount of a Formula (1) compound, stereoisomer thereof, and a pharmaceutically acceptable salt thereof; or use of said compound of Formula (1) to prepare a medicament for treating an inflammatory and/or immunological disease or disorder in an animal.

Immunomodulating o-het/aryl azalides

Defined herein are immunomodulating Formula (1) compounds, wherein R, Rand W are as defined herein, stereoisomers thereof, and pharmaceutically acceptable salts thereof; and compositions comprising said compounds. The invention also includes methods for treating an inflammatory and/or immunological disease or disorder in an animal by administering a therapeutically effective amount of a Formula (1) compound, stereoisomer thereof, and a pharmaceutically acceptable salt thereof; or use of said compound of Formula (1) to prepare a medicament for treating an inflammatory and/or immunological disease or disorder in an animal.

Immunomodulating trifluoromethyl-aminal azalides

Defined herein are immunomodulating Formula (1) compounds, wherein R, R, R, R and W are as defined herein, stereoisomers thereof, and pharmaceutically acceptable salts thereof; and compositions comprising said compounds. The invention also includes methods for treating or preventing an inflammatory and/or immunological disease or disorder in an animal by administering a therapeutically effective amount of a Formula (1) compound, stereoisomer thereof, or pharmaceutically acceptable salt thereof; or use of said Formula (1) compound to prepare a medicament for treating or preventing an inflammatory and/or immunological disease or disorder in an animal.

Immunomodulating azalides

Defined herein are immunomodulating Formula (1) compounds wherein R, R, R, R,

Immunomodulating urea azalides

The present invention provides cyclic depsipeptides of Formula (1), stereoisomers thereof, and veterinary acceptable salts thereof wherein each of R, R, R, R, L, and Lare as defined herein. The present invention also contemplates compositions, methods of treatment, and uses as a medicament to treat an animal for an endoparasitic infection with a Formula (1) compound.

Endoparasitic depsipeptides

Defined herein are immunomodulating Formula (1) compounds wherein R, R, R, R, Rand W are as defined herein, stereoisomers thereof, and pharmaceutically acceptable salts thereof; and compositions comprising said compounds. The invention also includes methods for treating an inflammatory and/or immunological disease or disorder in an animal by administering a therapeutically effective amount of a Formula (1) compound, stereoisomer thereof, and a pharmaceutically acceptable salt thereof; or use of said compound of Formula (1) to prepare a medicament for treating an inflammatory and/or immunological disease or disorder in an animal.

The present invention provides Formula (1) compounds that are gamma-carbolines, Formula (1) wherein R1, R1, R1, R1, R2, R3, and '-' are as defined herein; veterinary acceptable salts thereof, and stereoisomers thereof, which act as parasiticides, in particular, endoparasiticides.

Growing community of inventors

Kalamazoo, MI, United States of America

Tomasz Respondek