Warszawski Uniwersytet Medyczny

Nanovelos Sp. Z O.o.

Nanovelos S.a

Tomasz Ciach

Jaroslaw Deszczyński

Tomasz Mitek

Lukasz Nagraba

Artur Stolarczyk

Iga Wasiak

Agnieszka Sobiecka

Joanna Pietras

Pawel Zero

Pawel Zuk

Kinga Adamska

Piotr Pietrzak

Adam Kiciak

Mikolaj Chrominski

Wioletta Kosnik

Aleksandra Kulikowska-Darlak

Justyna Malkowska

The method, characterized in that, the powdered chitosan is dissolved in water to obtain a 5% solution, into which a 70-90% acetic acid is added and after the formation of the blank intramedullary nail and carrying a coagulating bath and neutralization bath it is subjected to a crosslinking bath in a solution formed from 0.5 to 2% of sodium tri-polyphosphate and 0.5% to 3% Na3PO4 for 24 to 48 hours in temperature of 50&#xb0; C. to 140&#xb0; C. and then it is subjected to the drying process, for a period of 6 to 10 days, and finally the surface of the blank is treated to form the intramedullary nail. The surface treatment is carried out until the surface of the intramedullary nail contains at least 20%-40% of the pore of the depth of 0.1 mm to 1 mm.

Method of manufacturing intramedullary nails made of chitosan for long bones fractures treatment

A process for the preparation of nanoparticles from polysaccharides and derivatives thereof, by their specific partial oxidation to produce aldehyde groups and attachment of compounds with amino or other group with the R&#x2014;NH2 bond which react with aldehyde groups, and a nanoparticle produced by such process.

Process for the preparation of polysaccharide nanoparticles

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Warsaw, Poland

Tomasz Ciach