Migenix, Inc.

Mitokor, Inc.

Tomas R Szabo

Soumitra S Ghosh

Robert E Davis

Walter H Moos

Yazhong Pei

Christen M Anderson

William Christensen Clevenger

Sandra Eileen Wiley

Scott W Miller

Compounds, compositions and methods treating arthritic disorders such as osteoarthritis or rheumatoid arthritis, and for treating other diseases associated with altered mitochondrial function, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The compounds of this invention have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein Rare as defined herein. The methods of this invention are directed to administering to a warm-blooded animal in need thereof an effective amount of a compound of structure (I), typically in the form of a pharmaceutical composition.

Aryl N-cyanoguanidines and methods related thereto

Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor

Compounds, compositions and methods treating arthritic disorders such as osteoarthritis or rheumatoid arthritis, and for treating other diseases associated with altered mitochondrial function, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The compounds of this invention have the following structure (I):including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein Rare as defined herein. The methods of this invention are directed to administering to a warm-blooded animal in need thereof an effective amount of a compound of structure (I), typically in the form of a pharmaceutical composition.

Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor.

Cobalt-porphyrin (Co-P) complexes for use as anti-obesity agents, and compositions and methods related thereto. The Co-P complexes exhibit reduced redox activity compared to cobalt mesoporphyrin (Co-MP) and cobalt protoporphyrin (Co-PP), which alleviates the deleterious effects associated with administration of Co-P associated with oxidative stress, particularly in the context of injection site toxicity.

Cobalt-porphyrin complexes and use thereof as an anti-obesity agent

Aryl-N-cyanoguanidines and methods related thereto

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San Diego, CA, United States of America

Tomas R Szabo