Pharmacia Ab

Biomatrix, Inc.

Tomas Malson

Bengt L Lindqvist

Leif G Ahrgren

Anthony N De Belder

The present invention relates to a crosslinked hyaluronic acid derivative in which the crosslinking has been achieved by means of reaction with a phosphorus-containing reagent, especially a derivative of an acid of phosphorus (V). The invention also relates to the methods of producing such a product as well as its use as a slow release depot for administration of hylaluronic acid or a medicament incorporated in the gel.

Crosslinked hyaluronate gels, their use and method for producing them

Method for extracapsular cataract extraction with or without posterior chamber intraocular lens implantation comprising chemical modification of the posterior surface of the lens capsule, at least in the optical portion of said capsule, for preventing cell attachment and growth.

Method for preventing secondary cataract

Material of polysaccharides containing carboxyl groups, and a process

A new method for preparation of sulfated polysaccharides by means of pyridine-chlorosulfonic acid reagents. The polysaccharide is before sulfation treated with a reducing agent, e.g. sodium borohydride.

Method for preparation of sulfated polysaccharides by treating the

A shaped article based upon cross-linked, possibly derivatized hyaluronic acid or a salt thereof is characterized in that it has a dry matter content of at least 65 percent by weight and a tensile strength of at least 2 N/cm.sup.2. The shaped article may be prepared by pressure-drying or freeze-drying a corresponding hyaluronic acid gel.

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Uppsala, Sweden

Tomas Malson