Ustav Organicke Chemie a Biochemie Av Cr, V.v.i.

Tomas Kraus

Zbigniew Zawada

Compounds of general formulae 6 and 13 where X is &#x2014;NH&#x2014;C(NH)&#x2550;N+Hor &#x2014;N+H, Y is a linear oligomer of arginine units terminated with an aminodimethylenamide unit (-Arg)n-NH&#x2014;(CH)&#x2014;NH, where n=6-10, or arginine-aminocaproic units (-Arg-Aca)n-NH, where n=6 to 10, A-&#x2550;CFCOO&#x2014; or Cl&#x2014; and m=1-2. Preparation and use of compounds of general formula 6 and 13 as carriers of nucleoside triphosphates across the cell membranes for the purpose of incorporation of modified nucleoside triphosphates into cellular DNA or RNA. Use of compounds of general formula 6 and 13 as carriers of nucleoside triphosphates across the cell membrane for determining the virostatic activities of modified nucleoside triphosphates. Use of compounds of general formula 6 and 13 as carriers of modified nucleoside triphosphates across the cell membrane for determining cell proliferation and S phase of the cell cycle.

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Prague, Czechia

Tomas Kraus