Katholieke Universiteit Leuven, Ku Leuven R&d

Remynd

Nv Remynd

K. U. Leuven R&d Remynd

Katholieke Universiteit Levun

Katholieke Universiteit Leuven

Tom Van Dooren

Gerard Griffioen

Arnaud Marchand

Patrick Chaltin

Amuri Kilonda

Sara Allasia

Veronica Rojas De La Parra

Verónica Rojas De La Parra

Stefaan Wera

Hein Roger Duhamel

Ellen Gommé

Nele Van Damme

Kristel Marie Edith Coupet

Tine Decruy

Marleen Lox

Ingrid Van Der Auwera

Sara Alassia

Ellen Gomme

Kristel Marie Coupet

This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterized by cytotoxic &#x3b1;-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds.

Indole amide derivatives and related compounds for use in the treatment of neurodegenerative diseases

This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterized by cytotoxic &#x3b1;-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds. The compounds have the formula (A1), wherein R, R, R, R, R, E, n, Y, Y, Y, Y, Y, B, R, and m are as defined in the claims. 

Compounds for the treatment of neurodegenerative diseases

This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterised by cytotoxic &#x3b1;-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds. The compounds have the formula (A1) wherein R, R, R, R, E, n, Y, Y, Y, Y, Y, L, B, R, and m are as defined in the claims. 

This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterized by cytotoxic &#x3b1;-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds. 

This invention provides specifically substituted 1,2,4-thiadiazole derivatives for use in the treatment of an &#x3b1;-synucleopathy such as Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, multiple system atrophy and Alzheimer's disease. This invention also provides various methods for producing such substituted 1,2,4-thiadiazole derivatives.

Thiadiazole derivatives for the treatment of neurodegenerative diseases

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Koningshooikt, Belgium

Tom Van Dooren