Memorial Sloan Kettering Cancer Center

O2micro International Limited

Evive Biotechnology (shanghai) Ltd

Generon Corporation Ltd.

Tom Tang

Guoxing Li

Marcel Van Den Brink

Sean Xiao

Alan Hanash

Caroline Lindemans

The present invention provides methods and compositions for the use of IL-22 for treating conditions of intestinal injury and inflammatory conditions such as graft vs. host disease. Specifically, IL-22 can be used to increase Intestinal Stem Cell (ISC) recovery and for enhancing immune reconstitution following allogeneic hematopoietic transplantation. In particularly preferred embodiments, the present invention provides methods of using therapeutic IL-22, including a dimeric form of IL-22, in therapeutic compositions for treating graft vs. host disease, including hepatic, thymic, gastrointestinal, or other graft vs. host disease in hematopoietic stem cell transplant patients and in patients with inflammatory intestinal conditions.

Methods of use for IL-22 in the treatment of gastrointestinal graft vs. host disease

A voltage generator is used for generating a voltage reference with high power supply rejection. One embodiment of the circuit includes a voltage regulator and a bandgap voltage circuit and an amplifier. The voltage regulator including an input node is coupled to an external power supply for generating a regulated voltage source. A bandgap voltage circuit includes a first and a second resistor and a first and a second transistor to generate a voltage difference between the base-to-emitter voltages of the first and the second transistors. The second resistor is coupled to the first resistor and the first transistor for generating the first predetermined voltage in response to the voltage difference. An amplifier circuit is coupled to the first transistor of the bandgap voltage circuit for receiving a first amplifying signal and generating an amplified signal so as to regulate the regulated voltage source.

Low power bandgap voltage reference circuit having multiple reference voltages with high power supply rejection ratio

Growing community of inventors

Shanghai, China

Tom Tang