Sanofi

Sanarus Technologies, LLC

Tom Oakley

Stuart Milne

Mark Pawulski

Karl Hewson

Matt Schumann

Russell L DeLonzor

James B Ross

Mathew J Nalipinski

Keith Turner

David J Foster

The driving configuration for a drug delivery device comprises an energy storing member () providing a force suitable for driving a bung () arranged in a container (), the bung being movable relative to the container. The energy storing member () is loaded by an alteration of its mechanical state with respect to a mounting element (), which is relocatable in such a manner that a force provided by the energy storing member when it is loaded is reduced by a relocation of the mounting element.

Driving configuration for a drug delivery device

The invention refers to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises at least one clicker mechanism () for generating a haptic and/or audible feedback during dose selecting, wherein the clicker mechanism () generates a different feed-back when selecting single units or multiples of single units.

Drug delivery device

The invention refers to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing (), a cartridge () containing a medicament and a last dose protection mechanism for preventing the selection of a dose, which exceeds the amount of medicament left in a cartridge (). This last dose protection mechanism comprises a first member (), which is rotatable in a first direction during dose selecting and in the opposite direction during dose dispensing, a second member () coupled to the first member () and to the housing () such that the second member is moved relative to the first member () and to the housing () upon rotation of the first member () and a third member () which is moved relative to the first and second member () during dose dispensing. Abutment of the second and third member () prevents increasing the selected dose.

A drive mechanism for a delivery device is presented. The drive mechanism comprises a housing () and a piston rod () having a longitudinal axis (x) and a piston rod feature (). The drive mechanism further comprises a drive member () being movable with respect to the housing (). The drive member () comprises a drive feature (). The drive feature () is selectively engageable with the piston rod feature () by the radial displacement of the drive member () with respect to the piston rod (). When the drive member () is in the first position, the drive member () is disengaged from the piston rod (), and when the drive member () is in the second position, the drive feature () is engaged with the piston rod feature (). When the drive member () moves distally with respect to the housing (), said distal movement is transferred to the piston rod () such that the piston rod () moves distally with respect to the housing ().

Drive mechanism for a delivery device

The invention relates to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a dosing element (), which rotates in a first direction during dose selecting and rotates in a second, opposite direction during dose dispensing, and a display () for indicating the selected dose. The display () comprises at least one belt () having symbols for indicating the selected dose and being coupled to the dosing element () such that a rotation of the dosing element () spools the belt ().

A drive mechanism () for a delivery device comprising a drive member () for driving a piston rod (); a moveable dose setting member () being disengaged from the drive member () in a dose setting state and being moveable in a drive direction in a dose delivery state, wherein the dose setting member () engages with the drive member () in the dose delivery state in such a manner that the movement of the dose setting member () in the drive direction is transferred to the drive member (); and a spring member () being coupled to the dose setting member () in such a manner that the movement of the dose setting member () in a setting direction loads the spring member () in the dose setting state, the spring force of the loaded spring member () driving the dose setting member () in the drive direction in the dose delivery state.

Drive mechanism

A drug delivery device for selecting and dispensing a number of user variable doses of a medicament includes a dose limiter for preventing the setting of a dose exceeding an amount of liquid left in a cartridge of the drug delivery device. The device includes a housing, a dose selector for selecting a dose by rotation relative to the housing, a dosing element, and a releasable clutch for rotationally coupling the dosing element to the dose selector during dose selecting and for rotationally decoupling the dosing element from the dose selector during dose dispensing. The clutch includes a male spline, a corresponding female spline and a curved or inclined surface which is orientated such that re-engagement of the clutch guides the male spline into a predefined rotational orientation with respect to the female spline.

A drug delivery device for selecting and dispensing a number of user variable doses of a medicament includes a dose limiter for preventing the setting of a dose, which exceeds the amount of liquid left in a cartridge of the drug delivery device. The device includes a cartridge containing liquid, a dosing element, which rotates during dose selecting, a last dose nut coupled to the dosing element during dose selecting such that rotation of the dosing element causes an axial movement of the last dose nut, and a stop element, which is provided on the dosing element and which blocks further movement of the last dose nut, if a dose is selected corresponding to the amount of liquid left in the cartridge. The device further includes a last dose sleeve rotationally coupled to the dosing element during dose selecting and rotationally decoupled from the dosing element during dose dispensing.

A drug delivery device for selecting and dispensing a number of user variable doses of a medicament includes a housing, a cartridge holder for receiving a cartridge, a lead screw and means for driving the lead screw during dose dispensing. The lead screw is coupled to the cartridge holder such that the cartridge holder is axially displaced with respect to the housing and the lead screw during dose dispensing.

The priming configuration comprises a piston rod (), a bung (), which is provided to be driven by the piston rod, and a movable element (), which is engaged with the piston rod. The movable element is arranged to be movable in a predefined direction () with respect to the piston rod by a user of the drug delivery device. A movement of the movable element in the predefined direction advances the piston rod in a further direction (), providing a priming of the drug delivery device before use. The predefined direction may especially be transverse to the further direction, and the further direction may especially be directed from the piston rod towards the bung (). A gap () or clearance between the piston rod () and the bung () can thus be removed, and the stiction of the bung () to the cartridge () can be reduced.

Priming configuration for a medical device and drug delivery device comprising a priming configuration

An assembly for a drug delivery device () is presented which comprises a housing () having a proximal end () and a distal end (), a cartridge, a plunger () which is movably retained in the cartridge () and a piston rod (). The assembly further comprises a rod displacement feature (). The assembly is configured such that, in an initial state of the assembly, the piston rod () and the rod displacement feature () are arranged such that movement of the rod displacement feature () from the first position to the second position is transferred to the piston rod () such that the piston rod () is moved with respect to the cartridge () and the assembly is switched from the initial state to a primed state. In the primed state, movement of the rod displacement feature () from the first position to the second position is not transferred to the piston rod ().

Assembly for a drug delivery device and method of operating the same

A display assembly is proposed, comprising: a body () defining a window () having an axial extension, an indication member () for providing information to be displayed in the window (), wherein the indication member () is movable relative to the body () for changing the information displayed in the window (), a selection member (), wherein the selection member () defines a masking section () and a non-masking section (), the selection member () is rotatable around a rotation axis (x) with respect to the body () and with respect to the indication member (), the non-masking section () and the masking section () partially overlap with the window () to define a displayed section () of the indication member (), and wherein the selection member () and the indication member () are coupled such that the displayed section () of the indication member () is axially displaced within the window ().

Display assembly and dispensing device

A cryoprobe for use in cryosurgery and other applications comprising a rigid outer tube, an inner coolant inlet tube. a short rigid penetrating segment extending distally from the distal end of the outer tube and a helical-shaped baffle having a heating element disposed about the outer surface of the inlet tube. The baffle is adapted to produce turbulent fluid flow improving heat transfer and is able to warm target tissue during rapid freezing and thawing cycles.

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Cambridge, United Kingdom

Tom Oakley