Theravance Biopharma R&d Ip, LLC

Tom M Lam

Robert Murray McKinnell

Erik Fenster

Anthony Francesco Palermo

Miroslav Rapta

Venkat R Thalladi

Jerry Nzerem

Marta Dabros

Breena Gloriana Fraga

Diana Jin Wang

Cameron Smith

Paul Allegretti

Mandy Loo

Christina Owens

Luke Boralsky

Philip Gerken

Gabrielle Elaine Dolgonos

Provided herein are compounds of formula (I): and pharmaceutically-acceptable salts thereof, where A, W, X, Y and Z are defined in the specification. The compounds of formula (I) and pharmaceutically-acceptable salts thereof are Janus kinase (JAK) inhibitors. Also provided herein are pharmaceutical compositions comprising such compounds; and methods of using such compounds to treat, e.g., inflammatory and fibrotic diseases, including respiratory diseases.

Imidazolo indazole compounds as JAK inhibitors

The disclosure provides compounds of formula (I): or a pharmaceutically-acceptable salt thereof, wherein the variables are defined in the specification, that are inhibitors of JAK kinases, particularly JAK3. The disclosure also provides pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat gastrointestinal inflammatory diseases.

Fused pyrimidine pyridinone compounds as JAK inhibitors

The invention provides compounds of formula (I): or a pharmaceutically-acceptable salt thereof, wherein the variables are defined in the specification, that are inhibitors of JAK kinases, particularly JAK3. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat gastrointestinal and other inflammatory diseases.

Imidazole and triazole containing bicyclic compounds as JAK inhibitors

The invention provides compounds of formula (I): or a pharmaceutically-acceptable salt thereof, wherein the variables are defined in the specification, that are inhibitors of JAK kinases, particularly JAK3. The invention also provides crystalline forms, pharmaceutical compositions comprising such compounds, methods of using such compounds to treat gastrointestinal and other inflammatory diseases, and processes and intermediates useful for preparing such compounds.

Pyrazolo and triazolo bicyclic compounds as JAK kinase inhibitors

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San Francisco, CA, United States of America

Tom M Lam