Zoetis Services LLC

Tom L McTier

Richard Andrew Ewin

Michael P Curtis

Paul D Johnson

Rajendran Vairagoundar

Graham M Kyne

Matthew W Bedore

Susan M Sheehan

Nathan Anthony Logan Chubb

Patrick F M Meeus

Christopher Scott Knauer

Kevin Evans

Guy Francis De Rose

Christoper S Knauer

Patrick FM Meeus

The present invention provides cyclic depsipeptides of Formula (1), stereoisomers thereof, and veterinary acceptable salts thereof wherein each of R, R, R, R, L, and L, are as defined herein. The present invention also contemplates compositions and methods of treatment as an endoparasiticide with a Formula (1) compound.

Endoparasitic depsipeptides

The present invention relates to a novel antiparasitic composition comprising an effective amount of a) a Formula (1) compound, wherein R, R, R, R, R, R, and n are as defined herein, stereoisomer thereof, or a pharmaceutical or veterinary acceptable salt thereof, b) a macrocyclic lactone or derivative thereof and c) optionally, at least one additional veterinary agent, and further comprising at least one veterinary or pharmaceutical acceptable carrier; and a method of treating an animal with a parasitic infection, by administering an effective amount of said composition to the animal in need thereof. 

Spirocyclic isoxazoline parasiticidal combinations

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Kalamazoo, MI, United States of America

Tom L McTier