Bayer Pharma Aktiengesellschaft

Tom Kinzel

Susanne Röhrig

Karl-Heinz Schlemmer

Adrian Tersteegen

Joachim Schuhmacher

Alexander Hillisch

Christoph Gerdes

Stefan Heitmeier

Anja Buchmüller

Johannes Köbberling

Michael Sperzel

Nils Burkhardt

Christian Stegmann

Martina Victoria Schmidt

Manuel Ellermann

Maria Köllnberger

Matthias Werner

Kristin Beyer

Martina Schäfer

Hartmut Schirok

Henrik Teller

Jürgen Klar

Eloisa Jimenez Nunez

Julia Strassburger

Jorma Haßfeld

Yolanda Cancho Grande

Yolanda Cancho-Grande

Philip Lienau

Bernd Riedl

Swen Allerheiligen

Kersten Matthias Gericke

Karen Engel

Michael Gerisch

Jorma Haβfeld

Julia Straβburger

Jan Stampfuß

Julia Straßburger

Gaelle Valot

Willem Jan Hengeveld

Jörg Heiermann

Imke Meyer

Martina Schafer

Anja Buchmuller

Jurgen Klar

The present application relates to novel substituted (aza)pyridopyrazolopyrimidinones and indazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired bleeding disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of menorrhagia, postpartum hemorrhage, hemorrhagic shock, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.

(Aza)pyridopyrazolopyrimidinones and indazolopyrimidinones and their use

The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

Substituted oxopyridine derivatives and use thereof cardiovascular disorders

The present application relates to novel substituted piperidinylpyrazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired hemostatic disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of heavy menstrual bleeding, postpartum hemorrhage, hemorrhagic shock, hemorrhagic cystitis, gastrointestinal hemorrhage, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.

Piperidinylpyrazolopyrimidinones and their use

Substituted oxopyridine derivatives and use thereof in the treatment of cardiovascular disorders

The invention relates to substituted benzoxazoles and to processes for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders, preferably of thrombotic or thromboembolic disorders.

Substituted benzoxazoles

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Düsseldorf, Germany

Tom Kinzel