Human Genome Sciences, Inc.

Cordis Corporation

Acorda Therapeutics, Inc.

Robert Falotico

Jonathon Z. Zhao

Dennis C. Argentieri

Tom J. Parry

Tom J Parry

Craig A Rosen

Jonathon Zhong Zhao

Anthony O Caggiano

Vivian Albert

Andrew R Blight

Les Sekut

Charles R Wescott

Indrajit Sanyal

Lili Huang

Jennifer F Iaci

Dennis C Argentieri

Jonathon Z Zhao

Binding polypeptides comprising specific amino acid sequences are disclosed that specifically bind ACE-2 protein or ACE-2-like polypeptides. The binding polypeptides can be used in methods of the invention for detecting, isolating, or purifying ACE-2 protein or ACE-2-like polypeptides in solutions or mixtures, or biological samples. The invention also relates to nucleic acid molecules encoding these ACE-2 binding polypeptides, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention also relates to methods and compositions for detecting, diagnosing, prognosing, preventing, treating or ameliorating a disease or disorder associated with aberrant ACE-2 or ACE-2 receptor expression or inappropriate function of ACE-2 or ACE-2 receptor, comprising use of ACE-2 binding polypeptides or fragments or variants thereof, that specifically bind to ACE-2.

Methods and compositions for modulating ACE-2 activity

The invention relates to the use of angiotensin II in combination with angiotesin 1-9 to potentiate angiotensin II activity. The invention also relates to the use of combinations of angiotensin II and angiotensin 1-9 to increase vasoconstriction and to treat disorders associated with low blood pressure.

Growing community of inventors

Walkersville, MD, United States of America

Tom J Parry