The United States of America As Represented by the Department of Health

Tom J Nelson

Daniel L Alkon

Rene Etcheberrigaray

Yi-Fan Han

Christopher S Kim

The present invention provides methods for the diagnosis of Alzheimer's disease using human cells. Specifically, one method detects differences between potassium channels in cells from Alzheimer's patient and normal donors, and differences in intracellular calcium concentrations between Alzheimer's and normal cells in response to chemicals known to increase intracellular calcium levels. Other methods detect differences between the memory associated GTP binding Cp20 protein levels between Alzheimer's and normal cells.

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Silver Spring, MD, United States of America

Tom J Nelson