Xenon Pharmaceuticals Inc.

Tom Hsieh

Shaoyi Sun

Sultan Chowdhury

Serguei Sviridov

Jianmin Fu

Shifeng Liu

Mikhail A Chafeev

Jianyu Sun

Nagasree Chakka

Alla Yurevna Zenova

Qi Jia

Mark Wood

Simon James Gauthier

Jean-Jacques Alexandre Cadieux

Jonathan David Langille

Lauren Fraser

Zoran Cikojevic

Amy Frances Douglas

Rajender Kamboj

Duanjie Hou

Vandna Raina

Robert Fraser

Mehran Seid Bagherzadeh

Mehran Bagherzadeh

Jian-Min Fu

Rajender K Kamboj

This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

Spiro-oxindole compounds and their use as therapeutic agents

This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein k, j, Q, R, R, R, R, R, R, R, R, and Rare as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment and/or prevention of hypercholesterolemia, benign prostatic hyperplasia, pruritis and cancer. 

Use of spiro-oxindole compounds as therapeutic agents

Spiro-oxindole compounds and their uses as therapeutic agents

This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, RR, R, R, R, R, R, R, and Rare as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.

This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R, R, R, R, R, R, R, R, and Rare as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.

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Burnaby, Canada

Tom Hsieh