The Hospital for Sick Children

Other

Tom Grunberger

Chaim M Roifman

Olga Rounova

Peter M Demin

There is described compounds of Formulae I, II, III, IV and V. The compounds of Formulae I, II, III, IV and/or V are useful: in therapeutic methods and compositions for modulating cell proliferation, in diagnostic assays and as research tools.

Compounds useful for modulating abnormal cell proliferation

There is described compounds of Formula I, and salts, solvates and hydrates thereof: wherein: R, Rand Rare each independently selected from OH, Calkyl, OCalkyl, OC(O)Calkyl, C(O)OCalkyl, NH, NH&#x2014;Calkyl, N(Calkyl)(Calkyl), C(O)NHCalkyl, C(O)N(Calkyl)(Calkyl), SH, SCalkyl, NO, CF, OCFand halogen; and Ar is an aromatic or heteroaromatic group chosen from benzene, naphthalene, quinoline, isoquinoline, indole, pyridine, pyrasine, pyrimidine, imidazole, furan and thiophene, unsubstituted or substituted with 1-4 substituents independently selected from OH, Calkyl, Calkoxy, Calkylenedioxy, NH, NH&#x2014;Calkyl, N(Calkyl)(Calkyl), SH, S&#x2014;Calkyl, NO, CF, OCFand halogen. The compounds of Formula I are useful: in therapeutic methods and compositions for modulating cell proliferation, in diagnostic assays and as research tools.

There is described compounds of Formula I, and salts, solvates and hydrates thereof: wherein: R, Rand Rare each independently selected from OH, Calkyl, OCalkyl, OC(O)Calkyl, C(O)OCalkyl, NH, NH&#x2014;Calkyl, N(Calkyl)(Calkyl), C(O)NHCalkyl, C(O)N(Calkyl)(Calkyl), SH, SCalkyl, NO, CF, OCFand halogen; and Ar is an aromatic or heteroaromatic group chosen from benzene, naphthalene, quinoline, isoquinoline, indole, pyridine, pyrasine, pyrimidine, imidazole, furan and thiophene, unsubstituted or substituted with 1&#x2013;4 substituents independently selected from OH, Calkyl, Calkoxy, Calkylenedioxy, NH, NH&#x2014;Calkyl, N(Calkyl)(C)(Calkyl), SH, S&#x2014;Calkyl, NO, CF, OCFand halogen. The compounds of Formula I are useful: in therapeutic methods and compositions for modulating cell proliferation, in diagnostic assays and as research tools.

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Toronto, Canada

Tom Grunberger